Skin as a manageable organ can provide direct or indirect information of tissue iron overload resulting from inherited disorders
as hemochromatosis. Patients with hemochromatosis were evaluated at three consecutive phases along the therapy programme.
Nuclear microprobe techniques were used to assess skin iron and Total Reflection X-ray Fluorescence to determine the plasma
iron concentrations. Results showed that iron pools were differently correlated at the three therapy phases. These variations
highlighted the value of skin iron content to assess organ iron deposition and therapy efficacy. Skin iron content can be
used for a better management of patients with iron overload pathologies.