Journal of Radioanalytical and Nuclear Chemistry
Volume/Issue:
Volume 283: Issue 1
Potential of radioiodinated anticancer compounds of traditional Chinese medicine for cancer therapy
Authors:
Min Yang Jiangsu Institute of Nuclear Medicine Key Laboratory of Nuclear Medicine Wuxi Jiangsu 214063 China

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Yu-pin Xu Jiangsu Institute of Nuclear Medicine Key Laboratory of Nuclear Medicine Wuxi Jiangsu 214063 China

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Dong-hui Pan Jiangsu Institute of Nuclear Medicine Key Laboratory of Nuclear Medicine Wuxi Jiangsu 214063 China

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Hong Din Jiangsu Institute of Nuclear Medicine Key Laboratory of Nuclear Medicine Wuxi Jiangsu 214063 China

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Li-zhen Wang Jiangsu Institute of Nuclear Medicine Key Laboratory of Nuclear Medicine Wuxi Jiangsu 214063 China

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Guang-ji Wang China Pharmaceutical University Key Laboratory of Pharmacokinetics and Drug Metabolism Nanjing Jiangsu 210009 China

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Pages:
189–191
Online Publication Date:
21 Jul 2009
Publication Date:
01 Jan 2010
Article Category:
Research Article
DOI:
https://doi.org/10.1007/s10967-009-0192-6
Keywords:
Radio iodination; Chinese medicine; Cancer therapy; Tumor uptake
Restricted access

Abstract  

23-Hydroxybetulinic acid (23-HBA) is the efficient antitumor compound extracted from the roots of a Chinese Medicinal Herb, Pulsatilla chinensis (Bge) Regel. To evaluate the effect of radioiodination on cytotoxicity, 23-HBA was radioiodinated with 125I. 125I-23-HBA could be prepared in high yields and good radiochemical purity and was characterized using reverse phase HPLC. In ICR mice bearing Liver Cancer HepA tumor, 125I-23-HBA showed a tumor uptake of 2.1% ID/g at 2 h p.i. and 0.15% ID/g at 48 h p.i on i.v. injection. When injected intratumorally, greater tumor uptake and retention was observed (20% ID/g at 2 h p.i. and 4.6% ID/g at 48 h p.i. respectively).

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Cover Journal of Radioanalytical and Nuclear Chemistry
Journal of Radioanalytical and Nuclear Chemistry
Print ISSN:
0236-5731
Online ISSN:
1588-2780

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Journal of Radionalytical and Nuclear Chemistry
Language English
Size A4
Year of
Foundation		 1968
Volumes
per Year		 1
Issues
per Year		 12
Founder Akadémiai Kiadó
Founder's
Address		 H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher Akadémiai Kiadó
Springer Nature Switzerland AG
Publisher's
Address		 H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible
Publisher		 Chief Executive Officer, Akadémiai Kiadó
ISSN 0236-5731 (Print)
ISSN 1588-2780 (Online)

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