Journal of Radioanalytical and Nuclear Chemistry
Volume/Issue:
Volume 283: Issue 3
The analysis of radiolysis impurities in 18F-FDG and methods of repurification
Authors:
Jinming Zhang The PLA General Hospital Department of Nuclear Medicine 100853 Beijing China

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Yungang Li The PLA General Hospital Department of Nuclear Medicine 100853 Beijing China

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Jian Liu The PLA General Hospital Department of Nuclear Medicine 100853 Beijing China

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Xiaojun Zhang The PLA General Hospital Department of Nuclear Medicine 100853 Beijing China

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Jiahe Tian The PLA General Hospital Department of Nuclear Medicine 100853 Beijing China

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Pages:
565–569
Online Publication Date:
19 Dec 2009
Publication Date:
01 Mar 2010
Article Category:
Research Article
DOI:
https://doi.org/10.1007/s10967-009-0408-9
Keywords:
18F-FDG; Radiolysis; Repurification
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Abstract  

To investigate the radio impurity in the radiolysis of 18F-FDG at high radiodose and radioconcentrated solutions and develop methods of repurification. The radiolysis of 18F-FDG was analyzed by TLC. The radio-impurity was confirmed by biodistribution and small animal PET/CT studies. 18F-FDG was unstable at high radioconcentrition over 37 GBq/mL or under basic condition. TLC, biodistribution and PET/CT all indicated that the main autoradiolysis byproduct was free fluoride ion. The radiolyzed 18F-FDG was repurified by solid-phase extraction (SPE) column. The repurified 18F-FDG had a radiochemical purity (RCP) of over 99% and significantly lower bone uptake than that was before repurification (P = 0.0003). There was a positive correlation between the recovery yield and the purity of 18F-FDG (R2 = 0.66).

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Cover Journal of Radioanalytical and Nuclear Chemistry
Journal of Radioanalytical and Nuclear Chemistry
Print ISSN:
0236-5731
Online ISSN:
1588-2780

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Journal of Radionalytical and Nuclear Chemistry
Language English
Size A4
Year of
Foundation		 1968
Volumes
per Year		 1
Issues
per Year		 12
Founder Akadémiai Kiadó
Founder's
Address		 H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher Akadémiai Kiadó
Springer Nature Switzerland AG
Publisher's
Address		 H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible
Publisher		 Chief Executive Officer, Akadémiai Kiadó
ISSN 0236-5731 (Print)
ISSN 1588-2780 (Online)

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