99mTc-DMSA complex preparation: the effect of pH and tin(II) chloride amount on reaction

I. Benkovský; R. Staník

doi:10.1007/s10967-010-0482-z

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Journal of Radioanalytical and Nuclear Chemistry

Volume/Issue:: Volume 284: Issue 1

^99mTc-DMSA complex preparation: the effect of pH and tin(II) chloride amount on reaction

Authors:

I. Benkovský

I. Benkovský Comenius University Department of Pharmaceutical Analysis and Nuclear Pharmacy, Faculty of Pharmacy Odbojárov 10 832 32 Bratislava Slovakia

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R. Staník

R. Staník Comenius University Department of Pharmaceutical Analysis and Nuclear Pharmacy, Faculty of Pharmacy Odbojárov 10 832 32 Bratislava Slovakia

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Pages:: 231–237

Online Publication Date:: 24 Feb 2010

Publication Date:: 01 Apr 2010

Article Category:: Research Article

DOI:: https://doi.org/10.1007/s10967-010-0482-z

Keywords:: Radiopharmaceuticals; 99mTc; DMSA complex; pH; SnCl2·2H2O

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Abstract

Labelling of meso-2,3-dimercaptosuccinic acid (DMSA) with technetium-99m was reinvestigated. Dependence of the ^99mTc-DMSA complex formation on the molar ratio of DMSA:reducing agent (SnCl₂·2H₂O) and pH was studied. Five different types of ^99mTc-DMSA complexes were determined. Especially three different complexes were established in the clinically used and prepared DMSA kit labelled with ^99mTc under alkaline condition. This radiopharmaceutical is used as imaging agent of the primary medullary carcinoma in the thyroid gland and different metastasis types. The existence of all complexes was observed by paper chromatography, paper electrophoresis and high performance liquid chromatography.

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Journal of Radioanalytical and Nuclear Chemistry

Print ISSN:: 0236-5731

Online ISSN:: 1588-2780

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Journal of Radionalytical and Nuclear Chemistry
Language	English
Size	A4
Year of Foundation	1968
Volumes per Year	1
Issues per Year	12
Founder	Akadémiai Kiadó
Founder's Address	H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher	Akadémiai Kiadó Springer Nature Switzerland AG
Publisher's Address	H-1117 Budapest, Hungary 1516 Budapest, PO Box 245. CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible Publisher	Chief Executive Officer, Akadémiai Kiadó
ISSN	0236-5731 (Print)
ISSN	1588-2780 (Online)