Authors:
I. Ibrahim Labeled Compound Department, Hot Lab Centre, Atomic Energy Authority, P.O. Box 13759, Cairo, Egypt

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M. Motaleb Labeled Compound Department, Hot Lab Centre, Atomic Energy Authority, P.O. Box 13759, Cairo, Egypt

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K. Attalah Labeled Compound Department, Hot Lab Centre, Atomic Energy Authority, P.O. Box 13759, Cairo, Egypt

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Abstract  

The optimization of the radiolabeling yield of ciprofloxacin analogous, norfloxacin, with technetium-99m (99mTc) was described. Dependence of the labeling yield of 99mTc–norfloxacin complex on the concentration of norfloxacin, SnCl2·2H2O content, pH of the reaction mixture and reaction time was studied. Norfloxacin was labeled with 99mTc at pH 3 with a labeling yield of 95.4% by using 5 mg norfloxacin, 50 μg SnCl2·2H2O and 30 min reaction time. The formed 99mTc–norfloxacin complex was stable for a time up to 3 h. Biological distribution of 99mTc–norfloxacin complex was investigated in experimentally induced inflammation rats using Staphylococcus aureus (bacterial infection model) and heat killed Staphylococcus aureus and turpentine oil (sterile inflammation model). In case of bacterial infection, the T/NT value for 99mTc–norfloxacin complex was found to be 6.9 ± 0.4 which was higher than that of the commercially available 99mTc–ciprofloxacin under the same experimental condition.

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Journal of Radionalytical and Nuclear Chemistry
Language English
Size A4
Year of
Foundation
1968
Volumes
per Year
1
Issues
per Year
12
Founder Akadémiai Kiadó
Founder's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher Akadémiai Kiadó
Springer Nature Switzerland AG
Publisher's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible
Publisher
Chief Executive Officer, Akadémiai Kiadó
ISSN 0236-5731 (Print)
ISSN 1588-2780 (Online)