(S)-2-((S)-2-(4-(3-[18F]fluoropropyl)benzamido)-3-phenylpropanamido)pentanedioic acid labeled with 18F

Yong He; Rui Ding; Hang Liu; Xiao Wang; Jing-Li Xu; Man Feng; Yu-Rong Chen; Chuan-Min Qi; Cheng Peng; Zhao-Hui Zhu; Yong-Hong Dang; Ming Wang; Yun-Chuan Ma

doi:10.1007/s10967-010-0633-2

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Journal of Radioanalytical and Nuclear Chemistry

Volume/Issue:: Volume 286: Issue 1

(S)-2-((S)-2-(4-(3-[¹⁸F]fluoropropyl)benzamido)-3-phenylpropanamido)pentanedioic acid labeled with ¹⁸F

Authors:

Yong He

Yong He Key Laboratory of Radiopharmaceutical, College of Chemistry, Beijing Normal University, Beijing, China

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Rui Ding

Rui Ding Key Laboratory of Radiopharmaceutical, College of Chemistry, Beijing Normal University, Beijing, China

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Hang Liu

Hang Liu Key Laboratory of Radiopharmaceutical, College of Chemistry, Beijing Normal University, Beijing, China

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Xiao Wang

Xiao Wang Key Laboratory of Radiopharmaceutical, College of Chemistry, Beijing Normal University, Beijing, China

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Jing-Li Xu

Jing-Li Xu Key Laboratory of Radiopharmaceutical, College of Chemistry, Beijing Normal University, Beijing, China

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Man Feng

Man Feng Key Laboratory of Radiopharmaceutical, College of Chemistry, Beijing Normal University, Beijing, China

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Yu-Rong Chen

Yu-Rong Chen Key Laboratory of Radiopharmaceutical, College of Chemistry, Beijing Normal University, Beijing, China

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Chuan-Min Qi

Chuan-Min Qi Key Laboratory of Radiopharmaceutical, College of Chemistry, Beijing Normal University, Beijing, China

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Cheng Peng

Cheng Peng PET Center of Xuan Wu Hospital, Beijing, China

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Zhao-Hui Zhu

Zhao-Hui Zhu Department of Nuclear Medicine, PUMC Hospital, CAMS and PUMC, Beijing, 100730 China

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Yong-Hong Dang

Yong-Hong Dang Department of Nuclear Medicine, PUMC Hospital, CAMS and PUMC, Beijing, 100730 China

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Ming Wang

Ming Wang Key Laboratory of Radiopharmaceutical, College of Chemistry, Beijing Normal University, Beijing, China

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Yun-Chuan Ma

Yun-Chuan Ma PET Center of Xuan Wu Hospital, Beijing, China

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Pages:: 135–140

Online Publication Date:: 04 Jun 2010

Publication Date:: 01 Oct 2010

Article Category:: Research Article

DOI:: https://doi.org/10.1007/s10967-010-0633-2

Keywords:: 18F; PET; Tumor

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Abstract

As degradation product of Antineoplaston A10 in vivo, phenylacetyl glutamine showed antitumor activities. According to literatures, we designed and radiosynthesized a phenylacetyl glutamine derivative, which was achieved under a mild reaction condition. Evaluations in vitro and in vivo were performed on tumor bearing mice. Excitingly, the radiochemical purity of (S)-2-((S)-2-(4-(3-fluoropropyl)benzamido)-3-phenylpropanamido)pentanedioic acid ([¹⁸F]FBPPA) was 98%, and besides the best radiochemical yield was up to 46%. T/Bl (Tumor/Blood) and T/M (Tumor/Muscle) ratios of [¹⁸F]FBPPA at 60 min post injection were 2.33 and 3.51. Meanwhile, it showed satisfied stability in vitro and in vivo, compared with 2-[¹⁸F]fluorodeoxyglucose ([¹⁸F]FDG). Although [¹⁸F]FBPPA deserved further studies to make optimizations on its structure, the results revealed it might become a potential PET imaging agent for detecting tumors.

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Journal of Radioanalytical and Nuclear Chemistry

Print ISSN:: 0236-5731

Online ISSN:: 1588-2780

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Journal of Radionalytical and Nuclear Chemistry
Language	English
Size	A4
Year of Foundation	1968
Volumes per Year	1
Issues per Year	12
Founder	Akadémiai Kiadó
Founder's Address	H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher	Akadémiai Kiadó Springer Nature Switzerland AG
Publisher's Address	H-1117 Budapest, Hungary 1516 Budapest, PO Box 245. CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible Publisher	Chief Executive Officer, Akadémiai Kiadó
ISSN	0236-5731 (Print)
ISSN	1588-2780 (Online)