A homemade modular PC-controlled radiochemistry system, used to separate the no-carrier-added 64Cu from irradiated electroplated solid cyclotron target 64Ni layers was developed. Upon irradiation the target layer is dissolved in diluted nitric acid, followed by selective liquid–liquid extraction of the 64Cu. The final purification step is achieved making use of an anion exchange column. All the separation procedures can be carried out remote-controlled with a minimized risk of operator errors within less than 2 h, with excellent processing yield (>95%).