Radio labeling, quality control and biodistribution of 99mTc-cefotaxime as an infection imaging agent

S. Mirshojaei; M. Gandomkar; R. Najafi; S. Sadat Ebrahimi; M. Babaei; A. Shafiei; M. Talebi

doi:10.1007/s10967-010-0826-8

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Journal of Radioanalytical and Nuclear Chemistry

Volume/Issue:: Volume 287: Issue 1

Radio labeling, quality control and biodistribution of ^99mTc-cefotaxime as an infection imaging agent

Authors:

S. Mirshojaei

S. Mirshojaei Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Science, Tehran, Iran

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M. Gandomkar

M. Gandomkar Nuclear Science Research School, Nuclear Science and Technology Research Institute (NSTRI), Atomic Energy Organization of Iran, P.O. Box 11365-3486, Tehran, Iran

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R. Najafi

R. Najafi Nuclear Science Research School, Nuclear Science and Technology Research Institute (NSTRI), Atomic Energy Organization of Iran, P.O. Box 11365-3486, Tehran, Iran

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S. Sadat Ebrahimi

S. Sadat Ebrahimi Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Science, Tehran, Iran

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M. Babaei

M. Babaei Nuclear Science Research School, Nuclear Science and Technology Research Institute (NSTRI), Atomic Energy Organization of Iran, P.O. Box 11365-3486, Tehran, Iran

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A. Shafiei

A. Shafiei Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Science, Tehran, Iran

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M. Talebi

M. Talebi Nuclear Science Research School, Nuclear Science and Technology Research Institute (NSTRI), Atomic Energy Organization of Iran, P.O. Box 11365-3486, Tehran, Iran

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Pages:: 21–25

Online Publication Date:: 11 Sep 2010

Publication Date:: 01 Jan 2011

Article Category:: Research Article

DOI:: https://doi.org/10.1007/s10967-010-0826-8

Keywords:: 99mTc; Cefotaxime; Radiolabeling; Infection imaging

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Abstract

Cefotaxime, a cephalosporin antibiotic, used to treat bacterial infections was investigated to label with ^99mTc. Labeling was performed using sodium dithionite as a reducing agent at 100 °C for 10 min and radiochemical analysis involved ITLC and HPLC methods. The stability of labeled antibiotic was checked in the presence of human serum at 37 °C up to 24 h. The maximum radiolabeling yield was 92 ± 2%. Bacterial binding assay was performed with S. aureus and the in vivo distribution was studied in mice. Images showed minimal accumulation in non-target tissues, with an average target/non-target ratio of 2.89 ± 0.58.

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Journal of Radioanalytical and Nuclear Chemistry

Print ISSN:: 0236-5731

Online ISSN:: 1588-2780

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Journal of Radionalytical and Nuclear Chemistry
Language	English
Size	A4
Year of Foundation	1968
Volumes per Year	1
Issues per Year	12
Founder	Akadémiai Kiadó
Founder's Address	H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher	Akadémiai Kiadó Springer Nature Switzerland AG
Publisher's Address	H-1117 Budapest, Hungary 1516 Budapest, PO Box 245. CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible Publisher	Chief Executive Officer, Akadémiai Kiadó
ISSN	0236-5731 (Print)
ISSN	1588-2780 (Online)