The effect of selected preparation variables on the radiochemical purity of 99mTc-EDDA-HYNIC-TOC

Betül Taşdelen

doi:10.1007/s10967-010-0703-5

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Journal of Radioanalytical and Nuclear Chemistry

Volume/Issue:: Volume 287: Issue 2

The effect of selected preparation variables on the radiochemical purity of ^99mTc-EDDA-HYNIC-TOC

Author:

Betül Taşdelen

Betül Taşdelen Çekmece Nuclear Research and Training Centre, Yarımburgaz Mah., Nükleer Araştırma Yolu, 34303 Istanbul, Turkey

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Pages:: 491–495

Online Publication Date:: 02 Aug 2010

Publication Date:: 01 Feb 2011

Article Category:: Research Article

DOI:: https://doi.org/10.1007/s10967-010-0703-5

Keywords:: 99m Tc-EDDA-HYNIC-TOC; HPLC; Peptide; RCP; HYNIC

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Abstract

[^99mTc-EDDA-HYNIC-D-Phe¹, Tyr³]-Ocreotide (^99mTc-EDDA-HYNIC-TOC) increasingly emerges to be an alternative tool for somatostatin receptor (SSTR) scintigraphy of neuroendocrine tumours. The high quality of this radiopharmaceutical and its uniformity are very important facts for application of this preparation in clinical practice. Various factors may influence the radiochemical purity (RCP) of certain reagent kits. Some of these include the amount of activity added to the reagent kit, heating time and the age of the formulated kit. The effect of these factors on RCP of ^99mTc-EDDA-HYNIC-TOC has been investigated using high performance liquid chromatography (HPLC) and instant thin layer chromatography (ITLC).

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Journal of Radioanalytical and Nuclear Chemistry

Print ISSN:: 0236-5731

Online ISSN:: 1588-2780

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Journal of Radionalytical and Nuclear Chemistry
Language	English
Size	A4
Year of Foundation	1968
Volumes per Year	1
Issues per Year	12
Founder	Akadémiai Kiadó
Founder's Address	H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher	Akadémiai Kiadó Springer Nature Switzerland AG
Publisher's Address	H-1117 Budapest, Hungary 1516 Budapest, PO Box 245. CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible Publisher	Chief Executive Officer, Akadémiai Kiadó
ISSN	0236-5731 (Print)
ISSN	1588-2780 (Online)