Authors:
Chuan-Min Qi Key Laboratory of Radiopharmaceutical, College of Chemistry, Beijing Normal University, Beijing, China

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Yong He Key Laboratory of Radiopharmaceutical, College of Chemistry, Beijing Normal University, Beijing, China

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Xiao Wang Key Laboratory of Radiopharmaceutical, College of Chemistry, Beijing Normal University, Beijing, China

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Man Feng Key Laboratory of Radiopharmaceutical, College of Chemistry, Beijing Normal University, Beijing, China

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Jing-Li Xu Key Laboratory of Radiopharmaceutical, College of Chemistry, Beijing Normal University, Beijing, China

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Rui Ding Key Laboratory of Radiopharmaceutical, College of Chemistry, Beijing Normal University, Beijing, China

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Hang Liu Key Laboratory of Radiopharmaceutical, College of Chemistry, Beijing Normal University, Beijing, China

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Yu-Rong Chen Key Laboratory of Radiopharmaceutical, College of Chemistry, Beijing Normal University, Beijing, China

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Fang Li Department of Nuclear Medicine, PUMC Hospital, CAMS and PUMC, Beijing, 100730 China

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Zhao-Hui Zhu Department of Nuclear Medicine, PUMC Hospital, CAMS and PUMC, Beijing, 100730 China

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Yong-Hong Dang Department of Nuclear Medicine, PUMC Hospital, CAMS and PUMC, Beijing, 100730 China

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Shu-Ting Zhang Key Laboratory of Radiopharmaceutical, College of Chemistry, Beijing Normal University, Beijing, China

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Ying Xie Institute of Medicine, Peking University, Beijing, 100191 China

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Abstract  

d-glucosamine at concentration of certain range could kill tumor cells without influencing normal cells. There are also some reports on the antitumor activity of d-glucosamine and its derivatives in murine models. It was therefore postulated that d-glucosamine might have the potential to invade tumor cells. We designed and radiosynthesized a glucosamine derivative, N-(2-[18F]fluoro-4-nitrobenzoyl)glucosamine ([18F]FNBG([18F]7)). Evaluations in vitro and in vivo were performed on tumor bearing mice. Excitingly, the radiochemical purity of [18F]FNBG([18F]7) was 99%, and besides the best radiochemical yield was up to 35%. The best T/Bl (Tumor/Blood) and T/M (Tumor/Muscle) ratios of [18F]FNBG([18F]7) were 4.40 and 4.84. Although [18F]FNBG([18F]7) deserved further studies, the results revealed it might become a potential PET imaging agent for detecting tumors.

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Journal of Radionalytical and Nuclear Chemistry
Language English
Size A4
Year of
Foundation
1968
Volumes
per Year
1
Issues
per Year
12
Founder Akadémiai Kiadó
Founder's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher Akadémiai Kiadó
Springer Nature Switzerland AG
Publisher's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible
Publisher
Chief Executive Officer, Akadémiai Kiadó
ISSN 0236-5731 (Print)
ISSN 1588-2780 (Online)