Journal of Radioanalytical and Nuclear Chemistry
Volume/Issue:
Volume 288: Issue 2
Synthesis and biological evaluation of a novel 99mTc complex of HYNIC-conjugated aminomethylenediphosphonate as a potential bone imaging agent
Authors:
Liqin Liu Department of Biological Science and Engineering, School of Chemical and Biological Engineering, University of Science and Technology Beijing, 30th Xueyuan Road, Haidian District, Beijing 100083, People’s Republic of China

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Guangrong Zhong Department of Biological Science and Engineering, School of Chemical and Biological Engineering, University of Science and Technology Beijing, 30th Xueyuan Road, Haidian District, Beijing 100083, People’s Republic of China

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Yaqian Wei Department of Biological Science and Engineering, School of Chemical and Biological Engineering, University of Science and Technology Beijing, 30th Xueyuan Road, Haidian District, Beijing 100083, People’s Republic of China

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Min Zhang Department of Biological Science and Engineering, School of Chemical and Biological Engineering, University of Science and Technology Beijing, 30th Xueyuan Road, Haidian District, Beijing 100083, People’s Republic of China

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Xuebin Wang Key Laboratory of Radiopharmaceuticals, Ministry of Education, College of Chemistry, Beijing Normal University, Beijing, 100875 People’s Republic of China

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Pages:
467–473
Online Publication Date:
03 Jan 2011
Publication Date:
01 May 2011
Article Category:
Research Article
DOI:
https://doi.org/10.1007/s10967-010-0942-5
Keywords:
Bone imaging agent; Bisphosphonate; 99mTc; HYNIC; Bifunctional chelator
Restricted access

Abstract  

A conjugate of 6-hydrazinopyridine-3-carboxylic acid (HYNIC) with aminomethylenediphosphonic acid (AMDP) was synthesized through a multiple-step reaction. HYNIC–AMDP could be labeled easily and efficiently with 99mTc using N-(2-hydroxy-1,1-bis(hydroxymethyl)ethyl)glycine (tricine) as coligand to form the 99mTc–HYNIC–AMDP complex in high yield (> 95%). Its partition coefficient indicated that it was a good hydrophilic complex. The biodistribution studies of 99mTc–HYNIC–AMDP in normal ICR mice showed that this complex had high bone uptake and low or negligible accumulation in non-target organs. As compared with 99mTc–MDP, 99mTc–HYNIC–AMDP had a higher bone uptake and the ratios of bone/blood and bone/muscle at early time after injection, suggesting that it could be potentially useful for bone imaging at an earlier time after injection according to further investigations of the biological behavior of this complex.

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Cover Journal of Radioanalytical and Nuclear Chemistry
Journal of Radioanalytical and Nuclear Chemistry
Print ISSN:
0236-5731
Online ISSN:
1588-2780

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Journal of Radionalytical and Nuclear Chemistry
Language English
Size A4
Year of
Foundation		 1968
Volumes
per Year		 1
Issues
per Year		 12
Founder Akadémiai Kiadó
Founder's
Address		 H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher Akadémiai Kiadó
Springer Nature Switzerland AG
Publisher's
Address		 H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible
Publisher		 Chief Executive Officer, Akadémiai Kiadó
ISSN 0236-5731 (Print)
ISSN 1588-2780 (Online)

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