Authors:
Liqin Liu Department of Biological Science and Engineering, School of Chemical and Biological Engineering, University of Science and Technology Beijing, 30th Xueyuan Road, Haidian District, Beijing 100083, People’s Republic of China

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Guangrong Zhong Department of Biological Science and Engineering, School of Chemical and Biological Engineering, University of Science and Technology Beijing, 30th Xueyuan Road, Haidian District, Beijing 100083, People’s Republic of China

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Yaqian Wei Department of Biological Science and Engineering, School of Chemical and Biological Engineering, University of Science and Technology Beijing, 30th Xueyuan Road, Haidian District, Beijing 100083, People’s Republic of China

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Min Zhang Department of Biological Science and Engineering, School of Chemical and Biological Engineering, University of Science and Technology Beijing, 30th Xueyuan Road, Haidian District, Beijing 100083, People’s Republic of China

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Xuebin Wang Key Laboratory of Radiopharmaceuticals, Ministry of Education, College of Chemistry, Beijing Normal University, Beijing, 100875 People’s Republic of China

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Abstract  

A conjugate of 6-hydrazinopyridine-3-carboxylic acid (HYNIC) with aminomethylenediphosphonic acid (AMDP) was synthesized through a multiple-step reaction. HYNIC–AMDP could be labeled easily and efficiently with 99mTc using N-(2-hydroxy-1,1-bis(hydroxymethyl)ethyl)glycine (tricine) as coligand to form the 99mTc–HYNIC–AMDP complex in high yield (> 95%). Its partition coefficient indicated that it was a good hydrophilic complex. The biodistribution studies of 99mTc–HYNIC–AMDP in normal ICR mice showed that this complex had high bone uptake and low or negligible accumulation in non-target organs. As compared with 99mTc–MDP, 99mTc–HYNIC–AMDP had a higher bone uptake and the ratios of bone/blood and bone/muscle at early time after injection, suggesting that it could be potentially useful for bone imaging at an earlier time after injection according to further investigations of the biological behavior of this complex.

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Journal of Radionalytical and Nuclear Chemistry
Language English
Size A4
Year of
Foundation
1968
Volumes
per Year
1
Issues
per Year
12
Founder Akadémiai Kiadó
Founder's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher Akadémiai Kiadó
Springer Nature Switzerland AG
Publisher's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible
Publisher
Chief Executive Officer, Akadémiai Kiadó
ISSN 0236-5731 (Print)
ISSN 1588-2780 (Online)