A novel electrochemical 99Mo/99mTc generator

Rubel Chakravarty; Meera Venkatesh; Ashutosh Dash

doi:10.1007/s10967-011-1113-z

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Journal of Radioanalytical and Nuclear Chemistry

Volume/Issue:: Volume 290: Issue 1

A novel electrochemical ⁹⁹Mo/^99mTc generator

Authors:

Rubel Chakravarty

Rubel Chakravarty Radiopharmaceuticals Division, Bhabha Atomic Research Centre, Trombay, Mumbai, 400 085 India

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Meera Venkatesh

Meera Venkatesh Radiopharmaceuticals Division, Bhabha Atomic Research Centre, Trombay, Mumbai, 400 085 India

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, and

Ashutosh Dash

Ashutosh Dash Radiopharmaceuticals Division, Bhabha Atomic Research Centre, Trombay, Mumbai, 400 085 India

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Pages:: 45–51

Online Publication Date:: 03 May 2011

Publication Date:: 01 Oct 2011

Article Category:: Research Article

DOI:: https://doi.org/10.1007/s10967-011-1113-z

Keywords:: Electrode potential; 99Mo/99mTc generator; (n, γ)99Mo; Radionuclidic purity

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Abstract

A novel electrochemical process to avail clinical grade ^99mTc from (n,γ)⁹⁹Mo has been demonstrated. The electrochemical parameters were optimized to maximize the ^99mTc yield with minimal ⁹⁹Mo contamination. ⁹⁹Mo/^99mTc generators containing up to 29.6 GBq (800 mCi) ⁹⁹Mo were developed and their performance were extensively evaluated for 10 days without changing the operating conditions. Very high radioactive concentration of ^99mTcO₄⁻ of acceptable quality, commensurate with hospital radiopharmacy requirements could be availed from the system with >90% yield. The compatibility of the product for the formulation of ^99mTc labeled radiopharmaceuticals such as ^99mTc-DMSA and ^99mTc-EC was found to be satisfactory in terms of high labeling yields. The proposed route represents an important step for enhancing the scope of accessing clinical grade ^99mTc from low specific activity (n, γ)⁹⁹Mo.

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Journal of Radioanalytical and Nuclear Chemistry

Print ISSN:: 0236-5731

Online ISSN:: 1588-2780

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Journal of Radionalytical and Nuclear Chemistry
Language	English
Size	A4
Year of Foundation	1968
Volumes per Year	1
Issues per Year	12
Founder	Akadémiai Kiadó
Founder's Address	H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher	Akadémiai Kiadó Springer Nature Switzerland AG
Publisher's Address	H-1117 Budapest, Hungary 1516 Budapest, PO Box 245. CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible Publisher	Chief Executive Officer, Akadémiai Kiadó
ISSN	0236-5731 (Print)
ISSN	1588-2780 (Online)