Journal of Radioanalytical and Nuclear Chemistry
Volume/Issue:
Volume 290: Issue 3
Development of an in vivo radionuclide generator by labeling bleomycin with 191Os
Authors:
Mina Jamre Faculty of Nuclear Engineering and Physics, Amirkabir University of Technology, Tehran, Iran

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Nafise Salek Faculty of Nuclear Engineering and Physics, Amirkabir University of Technology, Tehran, Iran

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Amir Jalilian Radiopharmaceutical Research and Development Lab (RRDL), Nuclear Science and Technology Research Institute (NSTRI), 14155-1339 Tehran, Iran

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Leila Moghaddam Radiopharmaceutical Research and Development Lab (RRDL), Nuclear Science and Technology Research Institute (NSTRI), 14155-1339 Tehran, Iran

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Mojtaba Shamsaee Faculty of Nuclear Engineering and Physics, Amirkabir University of Technology, Tehran, Iran

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Mohammad Mazidi Radiopharmaceutical Research and Development Lab (RRDL), Nuclear Science and Technology Research Institute (NSTRI), 14155-1339 Tehran, Iran

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Mohammad Ghannadi-Maragheh Radiopharmaceutical Research and Development Lab (RRDL), Nuclear Science and Technology Research Institute (NSTRI), 14155-1339 Tehran, Iran

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Pages:
543–549
Online Publication Date:
25 Jun 2011
Publication Date:
01 Dec 2011
Article Category:
Research Article
DOI:
https://doi.org/10.1007/s10967-011-1288-3
Keywords:
Bleomycin; 191Os; Biodistribution; Radiolabeling; Imaging
Restricted access

Abstract  

Bleomycin (BLM) has been labeled with various radioisotopes and widely used in therapy and diagnosis. 191Os is a parent radionuclide with 15.4 day half-life and decays by beta emission to 191mIr, which is a radionuclide with 4.96 s half-life. BLM was labeled with 191Os-hexachloro-osmate and its distribution and stability in wild-type mice was determined. The complex was obtained at the pH 2 in normal saline at 90 °C in 48 h. Radio-TLC showed an overall radiochemical yield of 93–97%, radio-chemical purity > 97%. The biodistribution study for 191Os-hexachloro-osmate and 191Os-BLM were carried in wild type-mice up to 14 days. Lungs, liver and spleen uptake increased 24–72 h after administration of 191Os-BLM. 24 h after administration, the radioactivity of the kidney increased and remained constant.

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Cover Journal of Radioanalytical and Nuclear Chemistry
Journal of Radioanalytical and Nuclear Chemistry
Print ISSN:
0236-5731
Online ISSN:
1588-2780

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Journal of Radionalytical and Nuclear Chemistry
Language English
Size A4
Year of
Foundation		 1968
Volumes
per Year		 1
Issues
per Year		 12
Founder Akadémiai Kiadó
Founder's
Address		 H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher Akadémiai Kiadó
Springer Nature Switzerland AG
Publisher's
Address		 H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible
Publisher		 Chief Executive Officer, Akadémiai Kiadó
ISSN 0236-5731 (Print)
ISSN 1588-2780 (Online)

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