Journal of Radioanalytical and Nuclear Chemistry
Volume/Issue:
Volume 292: Issue 3
Polymer-coated magnetic nanoparticles for rapid bioassay of 90Sr in human urine samples
Authors:
Zack Varve Department of Chemistry, Carleton University, 1125 Colonel By Drive, Ottawa, ON K1S 5B6, Canada

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Edward Lai Department of Chemistry, Carleton University, 1125 Colonel By Drive, Ottawa, ON K1S 5B6, Canada

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Chunsheng Li Radiation Protection Bureau, Health Canada, 775 Brookfield Road, Ottawa, ON K1A 1C1, Canada

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Baki Sadi Radiation Protection Bureau, Health Canada, 775 Brookfield Road, Ottawa, ON K1A 1C1, Canada

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Gary Kramer Radiation Protection Bureau, Health Canada, 775 Brookfield Road, Ottawa, ON K1A 1C1, Canada

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Pages:
1411–1415
Online Publication Date:
17 Jan 2012
Publication Date:
01 Jun 2012
Article Category:
Research Article
DOI:
https://doi.org/10.1007/s10967-012-1621-5
Keywords:
90Sr; 90Y; Human urine; Magnetic nanoparticles; Polymer coating; Phosphate elution; Liquid scintillation counting; Bioassay
Restricted access

Abstract  

A rapid bioassay for 90Sr was developed involving preconcentration of 90Sr/90Y from human urine samples with a cation exchange polymer (poly–acrylamido–methyl–propanesulfonic acid) coated onto magnetic nanoparticles, followed by selective elution of 90Sr (over 90Y) with phosphate for determination by liquid scintillation analysis. The minimum detectable activity for this method (4.9 ± 0.5 Bq/L) is lower than the required sensitivity of 19 Bq/L for 90Sr in human urine samples, as defined in the requirements for radiation emergency bioassay techniques for the public and first responders based on the dose threshold for possible medical attention recommended by the International Commission on Radiological Protection. The relative bias was 9.2%, the relative precision was 3.2%, and the linear dynamic range covered 12–600 Bq/L. This simple and rapid bioassay method is found to be in compliance with the HPS ANSI N13.30 performance criteria for radiobioassay.

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Cover Journal of Radioanalytical and Nuclear Chemistry
Journal of Radioanalytical and Nuclear Chemistry
Print ISSN:
0236-5731
Online ISSN:
1588-2780

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Journal of Radionalytical and Nuclear Chemistry
Language English
Size A4
Year of
Foundation		 1968
Volumes
per Year		 1
Issues
per Year		 12
Founder Akadémiai Kiadó
Founder's
Address		 H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher Akadémiai Kiadó
Springer Nature Switzerland AG
Publisher's
Address		 H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible
Publisher		 Chief Executive Officer, Akadémiai Kiadó
ISSN 0236-5731 (Print)
ISSN 1588-2780 (Online)

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