The radionuclide iron-55 (T1/2 = 2.73 a) decays by electron capture and consists of small percentage of weak gamma rays. 55Fe can be employed for industrial, medical and agriculture applications. First, calculation of the excitation functions of
iron-55 via the 55Mn(p,n)55Fe, 55Mn(d,2n)55Fe and 54Fe(α,n2p)55Fe reactions were performed and investigated by ALICE/ASH (hybrid model) and EMPIRE (3.1 Rivoli) codes. Then the required
thickness of the target was calculated by the SRIM code; moreover, the theoretical physical yields of 55Fe production reactions were obtained. Consequently, the best reaction, 55Mn(p,n)55Fe, was suggested to take full benefit of the excitation function and to avoid formation of radioactive and non-radioactive
impurities as far as possible. Furthermore, the optimum energy range were predicted to be 2–18 MeV and the theoretical physical
yield were obtained to be 0.35 MBq/μA h. Lastly, manganese dioxide (MnO2) powder was used to prepare the thick layer; it was deposited on an elliptical copper substrate by means of sedimentation
method. Target was irradiated at 20 μA current and 18 MeV proton beam. The radioactivity of 55Fe was determined via X-ray detector.