A method for separation of uranium, plutonium and neodymium in a cation exchange column is presented and discussed. The nitric acid fuel and fission product solution is, through addition of sulphuric acid in sulfate transferred and absorbed on a H+-form Dowex 50X8 cation exchanger. Afterwards uranium and plutonium both segregate as oxalate complexes, while neodymium attached to the same column is separated with α-hydroxy-isobutyric acid (α-HIBS). A detailed procedure is given.