Authors:
N. Sivaprasad Radiopharmaceuticals Section, Isotope Group, Bhabha Atomic Research Centre, 400 085 Bombay, India

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Miss Thomas Radiopharmaceuticals Section, Isotope Group, Bhabha Atomic Research Centre, 400 085 Bombay, India

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K. Shah Radiopharmaceuticals Section, Isotope Group, Bhabha Atomic Research Centre, 400 085 Bombay, India

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R. Mani Radiopharmaceuticals Section, Isotope Group, Bhabha Atomic Research Centre, 400 085 Bombay, India

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Abstract  

A sensitive and specific radioimmunossay procedure (RIA) has been developed for the measurement of Human Placental Lactogen (HPL). Pure HPL has been labelled with125I and a specific activity of 100 μCi/μgm of HPL has been attained. Dextran-coated charcoal has been employed to separate the bound from the free hormone in radioimmuno-assay. The sensitivity of this technique has been found to be 0.2 ng of HPL. Intraassay and inter assay variations have been found to be less than 10%. This procedure has been adopted to establish the normal range of HPL in pregnant women at different periods of gestation, and to evaluate risk pregnancies.

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Journal of Radionalytical and Nuclear Chemistry
Language English
Size A4
Year of
Foundation
1968
Volumes
per Year
1
Issues
per Year
12
Founder Akadémiai Kiadó
Founder's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher Akadémiai Kiadó
Springer Nature Switzerland AG
Publisher's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible
Publisher
Chief Executive Officer, Akadémiai Kiadó
ISSN 0236-5731 (Print)
ISSN 1588-2780 (Online)