Journal of Radioanalytical and Nuclear Chemistry
Volume/Issue:
Volume 59: Issue 2
The stability of99mTc phosphorus compounds in plasma both in vivo and in vitro
Authors:
A. Owunwanne University of Rochester School of Medicine and Dentistry Rochester New York (USA)

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R. O'Mara University of Rochester School of Medicine and Dentistry Rochester New York (USA)

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C. O'Brien University of Rochester School of Medicine and Dentistry Rochester New York (USA)

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Pages:
571–578
Online Publication Date:
09 Jan 2007
Publication Date:
01 Sep 1980
Article Category:
Research Article
DOI:
https://doi.org/10.1007/bf02517301
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Abstract  

The in vivo and in vitro stability of99mTc hydroxyethlylidene diphosphonate, 99mTc methylenediphosphonate and99mTc pyrophosphate in plasma has been studied using paper chromatographic technique as the analytical tool. The results indicate that the amounts of99mTc activity found both at the origin and Rf range of99mTcO4− for in vivo experiments are slightly greater than those for either in vitro or control experiments. However, this amount of99mTc activity represents about 0.16–0.4% of the injected dose. Therefore, it is suggested that99mTc phosphorus radiopharmaceuticals are stable in vivo and neither oxidation nor hydrolysis of these bone imaging agents occurs in the blood.

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Cover Journal of Radioanalytical and Nuclear Chemistry
Journal of Radioanalytical and Nuclear Chemistry
Print ISSN:
0236-5731
Online ISSN:
1588-2780

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Journal of Radionalytical and Nuclear Chemistry
Language English
Size A4
Year of
Foundation		 1968
Volumes
per Year		 1
Issues
per Year		 12
Founder Akadémiai Kiadó
Founder's
Address		 H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher Akadémiai Kiadó
Springer Nature Switzerland AG
Publisher's
Address		 H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible
Publisher		 Chief Executive Officer, Akadémiai Kiadó
ISSN 0236-5731 (Print)
ISSN 1588-2780 (Online)

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