Authors:
M. Lagunas-Solar University of California Crocker Nuclear Laboratory Davis California (USA)

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S. Wilkins University of California Crocker Nuclear Laboratory Davis California (USA)

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D. Paulson University of California Crocker Nuclear Laboratory Davis California (USA)

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Abstract  

Rh coordination complexes having anticancer properties have been known since 1931.101mRh has excellent decay properties and can be used to study the biological behaviour of Rh-complexesin vivo. A method for its production using cyclotron technology is described. The yields for101Pd,100Pd,101mRh, and100Rh, produced by proton bombardment of natural Pd, are reported for proton energies from 40- to 60-MeV.101mRh thick-target yields of 0.9 m Ci/μAh at 32.7 h EOB were measured. A method is proposed to prepare No Carrier Added (NCA)101mRh in a chemical form suitable for labeling and/or clinical research,101mRh-chloride,101mRh-acetate, and101mRh-DTPA complexes were prepared and used to determine theirin vivo distribution in tumor-bearing laboratory animals. Results of these studies indicated the kidneys and liver being the primary rarget organs. However, bone and tumor uptakes for101mRh-DTPA were significantly different, with bone levels continuing to increase at 48-h and tumor levels maximizing at ≈24-h post administration. The half-life of101mRh was measured as 4.26±0.01 days.

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Journal of Radionalytical and Nuclear Chemistry
Language English
Size A4
Year of
Foundation
1968
Volumes
per Year
1
Issues
per Year
12
Founder Akadémiai Kiadó
Founder's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher Akadémiai Kiadó
Springer Nature Switzerland AG
Publisher's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible
Publisher
Chief Executive Officer, Akadémiai Kiadó
ISSN 0236-5731 (Print)
ISSN 1588-2780 (Online)