Comparative evaluation of labelling patterns and turnover of lipids, tagged by 15 /p-123I-phenyl-/ pentadecanoic and 1-14C-palmitic acid

S. Reske; W. Sauer; H. Machulla; E. Knust; K. Reichmann; C. Winkler

doi:10.1007/bf02166719

Journal of Radioanalytical and Nuclear Chemistry

Volume/Issue:: Volume 86: Issue 4

Comparative evaluation of labelling patterns and turnover of lipids, tagged by 15 /p-¹²³I-phenyl-/ pentadecanoic and 1-¹⁴C-palmitic acid

Authors:

S. Reske

S. Reske Institut für klinische und experimentelle Nukleomedizin der Universität Bonn D-5300 Bonn 1 FRG

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W. Sauer

W. Sauer Institut für klinische und experimentelle Nukleomedizin der Universität Bonn D-5300 Bonn 1 FRG

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H. Machulla

H. Machulla Universitätsklinikum Institut für Medizinische Strahlenphysik und Strahlenbiologie Hufelandstr. 55 D-4300 Essen FRG

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E. Knust

E. Knust Universitätsklinikum Institut für Medizinische Strahlenphysik und Strahlenbiologie Hufelandstr. 55 D-4300 Essen FRG

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K. Reichmann

K. Reichmann Institut für klinische und experimentelle Nukleomedizin der Universität Bonn D-5300 Bonn 1 FRG

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, and

C. Winkler

C. Winkler Institut für klinische und experimentelle Nukleomedizin der Universität Bonn D-5300 Bonn 1 FRG

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Pages:: 231–245

Online Publication Date:: 20 Sep 2005

Publication Date:: 17 Jun 1984

Article Category:: Research Article

DOI:: https://doi.org/10.1007/bf02166719

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Abstract

Uptake and turnover of chloroform/methanol extractable tissue lipids labelled in vivo simultaneously with 15/p-¹²³I-phenyl-/pentadecanoic and l-¹⁴C-palmitic acid were compared. Lipid turnover studies were performed in fasted pentobarbital-anaesthetized Wistar rats in tissues with highly varying free fatty acid turnover rates. In all tissues investigated, i.e. heart, lung, liver, spleen and kidneys, both tracers labelled nearly identical lipid fraction. Main tracer uptake was found in free fatty acids, phospholipids, diglycerides and triglycerides. A highly significant correlation of uptake and turnover in main tissue lipid fraction indicated an essentially identical metabolic pathway of both tracers in intermediary tissue lipid metabolism. Concordant tracer uptake and turnover patterns in tissue of lipids with highly varying free fatty acid metabolic rates suggested that intrinsic metabolic activity of the tissue and respective lipid fraction was the major determinant of metabolic handling of both iodophenyl fatty- and palmitic acid. Thus, the feasibility of iodophenylpentadecanoic acid as free fatty acid tracer for studying tissue lipid metabolism is demonstrated.

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Journal of Radioanalytical and Nuclear Chemistry

Print ISSN:: 0236-5731

Online ISSN:: 1588-2780

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Journal of Radionalytical and Nuclear Chemistry
Language	English
Size	A4
Year of Foundation	1968
Volumes per Year	1
Issues per Year	12
Founder	Akadémiai Kiadó
Founder's Address	H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher	Akadémiai Kiadó Springer Nature Switzerland AG
Publisher's Address	H-1117 Budapest, Hungary 1516 Budapest, PO Box 245. CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible Publisher	Chief Executive Officer, Akadémiai Kiadó
ISSN	0236-5731 (Print)
ISSN	1588-2780 (Online)