Authors:
G. Del Fioe Université de Liège Centre de Recherches de Cyclotron /C.R.C./ Sart Tilman B-4000 Liège Belgium

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J. Peters Université de Liège Centre de Recherches de Cyclotron /C.R.C./ Sart Tilman B-4000 Liège Belgium

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L. Quaglia Université de Liège Centre de Recherches de Cyclotron /C.R.C./ Sart Tilman B-4000 Liège Belgium

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J. Piette Université de Liège Centre de Recherches de Cyclotron /C.R.C./ Sart Tilman B-4000 Liège Belgium

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R. Cantineau Université de Liège Centre de Recherches de Cyclotron /C.R.C./ Sart Tilman B-4000 Liège Belgium

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C. De Landsheere Université de Liège Centre de Recherches de Cyclotron /C.R.C./ Sart Tilman B-4000 Liège Belgium

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D. Raets Université de Liège Centre de Recherches de Cyclotron /C.R.C./ Sart Tilman B-4000 Liège Belgium

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P. Rigo Université de Liège Centre de Recherches de Cyclotron /C.R.C./ Sart Tilman B-4000 Liège Belgium

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Abstract  

The synthesis of11C-acetate has been achieved via carbonation of methyl magnesium bromide with11C-labelled carbon dioxide. Using this procedure, 7.4 GBq /200 mCi/ of11CO2 produced by the14N/P,/11C nuclear reaction, was converted, within 20 min into11C-acetate with an activity higher than 2.22 GBq /60 mCi/. Chemical and biologic quality control shows that the product is pure, sterile, and pyrogen-free and therefore suitable for human use. Handling considerable amounts of activity has led us to automate the11C-acetate synthesis. The different parts of the system-programmable controller, sensors, automatic neutralization system-are described in detail.

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Journal of Radionalytical and Nuclear Chemistry
Language English
Size A4
Year of
Foundation
1968
Volumes
per Year
1
Issues
per Year
12
Founder Akadémiai Kiadó
Founder's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher Akadémiai Kiadó
Springer Nature Switzerland AG
Publisher's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible
Publisher
Chief Executive Officer, Akadémiai Kiadó
ISSN 0236-5731 (Print)
ISSN 1588-2780 (Online)