99mTc-labelled compounds prepared with tungsten(III) as the reducing agent

Š. Vilček; M. Kalinčák; V. Macháň

doi:10.1007/bf02037012

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Journal of Radioanalytical and Nuclear Chemistry

Volume/Issue:: Volume 88: Issue 2

^99mTc-labelled compounds prepared with tungsten(III) as the reducing agent

Authors:

Š. Vilček

Š. Vilček University of Vererinary Medicine Department of Infectology Komenského 73, 041 81 Košice (Czechoslovakia)

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M. Kalinčák

M. Kalinčák Institute of Radioecology and Applied Nuclear Techniques Komenského 9 Košice (Czechoslovakia)

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, and

V. Macháň

V. Macháň Institute of Radioecology and Applied Nuclear Techniques Komenského 9 Košice (Czechoslovakia)

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Pages:: 359–367

Online Publication Date:: 13 Aug 2005

Publication Date:: 17 Feb 1985

Article Category:: Research Article

DOI:: https://doi.org/10.1007/bf02037012

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Abstract

The application of K₃W₂Cl₉ as reducing agent in preparation of^99mTc-labelled compounds is described. Pertechnetate reduction was carried out in solutions of pH 2 and also of pH 5.5. DTPA, citrate, gluconate, HEDSPA and MDP were successfully labelled. Two types of labelled gluconate complexes were obtained. Complex I exhibited in rats an increased^99mTc affinity to kidneys (21%). Complex II exhibited an increased^99mTc affinity to bone (8.7%). Two types of labelled HEDSPA preparations were obtained: one yielded 29%^99mTc activity in bone, the other type exhibited only 13.4%. The results indicated the absence of mixed complexes.

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Journal of Radioanalytical and Nuclear Chemistry

Print ISSN:: 0236-5731

Online ISSN:: 1588-2780

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Journal of Radionalytical and Nuclear Chemistry
Language	English
Size	A4
Year of Foundation	1968
Volumes per Year	1
Issues per Year	12
Founder	Akadémiai Kiadó
Founder's Address	H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher	Akadémiai Kiadó Springer Nature Switzerland AG
Publisher's Address	H-1117 Budapest, Hungary 1516 Budapest, PO Box 245. CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible Publisher	Chief Executive Officer, Akadémiai Kiadó
ISSN	0236-5731 (Print)
ISSN	1588-2780 (Online)