Authors:
M. Diksic Montreal Neutrological Institute PET Research Unit H3A 2B4 Montreal (Canada)

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S. Farrokhzad

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Y. Yamamoto

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W. Feindel

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Abstract  

This paper decribes syntheses for the11C-labelled chemotherapeutic drug, CCNU,11C-labelled BFNU and CFNU (analogs of BCNU) as well as an improved synthesis for11C-BCNU. Also discussed are procedures for the separation of dual isomers in the case of11C-labelled CCNU and CFNU. The specific activity of these no-carrier-added radiopharmaceuticals was approximately 104 lower than expected for a carrier-free product. The syntheses were normally finished 20–25 min after the end of the collection of11C-COCl2. Chemical and radiochemical purity of the final product, as determined by HPLC and TLRC respectively, was at least 98%. The syntheses yielded 10–25 mCi of nitrosourea ready for use in PET studies.

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Journal of Radionalytical and Nuclear Chemistry
Language English
Size A4
Year of
Foundation
1968
Volumes
per Year
1
Issues
per Year
12
Founder Akadémiai Kiadó
Founder's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher Akadémiai Kiadó
Springer Nature Switzerland AG
Publisher's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible
Publisher
Chief Executive Officer, Akadémiai Kiadó
ISSN 0236-5731 (Print)
ISSN 1588-2780 (Online)