Comparative study of different gels for quality control of99mTc-radiopharmaceutical kits

N. Agha; H. Karim; N. Dahir

doi:10.1007/bf02037317

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Journal of Radioanalytical and Nuclear Chemistry

Volume/Issue:: Volume 90: Issue 1

Comparative study of different gels for quality control of^99mTc-radiopharmaceutical kits

Authors:

N. Agha

N. Agha Nuclear Research Centre Radioisotope Production Department P. O. Box 765 Baghdad (Iraq)

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H. Karim

H. Karim Nuclear Research Centre Radioisotope Production Department P. O. Box 765 Baghdad (Iraq)

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N. Dahir

N. Dahir Nuclear Research Centre Radioisotope Production Department P. O. Box 765 Baghdad (Iraq)

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Pages:: 3–13

Online Publication Date:: 14 Aug 2005

Publication Date:: 17 May 1985

Article Category:: Research Article

DOI:: https://doi.org/10.1007/bf02037317

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Abstract

The available six types of Sephadex and one type of Sepharose have been applied in the separation of technetium fractions in^99mTc-labelled radiopharmaceuticals produced in our laboratory using the GCS technique. By this technique the chemical state and the percentage of^99mTc-fractions have been determined. The resolution efficiency of some gel types were found to be significantly influenced by the pH of the eluent. The results obtained from the experiments indicated that Sephadex G-25 Fine was the best and can be routinely used in the radiochemical analysis of the following kits:^99mTc-HSA,^99mTc-DTPA and^99mTc-HIDA and G-100 for^99mTc-PYP. With^99mTc-HSA and^99mTc-PYP kits, 0.9% NaCl eluents at pH 3.2 and pH 2 to 2.5, respectively, were found to be necessary for the separation of^99mTc-fractions. G-50 Fine was found to be the best gel between the others in the separation of^99mTc-fractions in testing of the weak radiopharmaceuticals,^99mTc-GH and^99mTc-MDP. The development of^99mTc-MDP with the eluent at the same pH as the preparation gives negligible interaction effect.

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Journal of Radioanalytical and Nuclear Chemistry

Print ISSN:: 0236-5731

Online ISSN:: 1588-2780

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Journal of Radionalytical and Nuclear Chemistry
Language	English
Size	A4
Year of Foundation	1968
Volumes per Year	1
Issues per Year	12
Founder	Akadémiai Kiadó
Founder's Address	H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher	Akadémiai Kiadó Springer Nature Switzerland AG
Publisher's Address	H-1117 Budapest, Hungary 1516 Budapest, PO Box 245. CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible Publisher	Chief Executive Officer, Akadémiai Kiadó
ISSN	0236-5731 (Print)
ISSN	1588-2780 (Online)