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  • 1 The George Washington University Medical Center Division of Radiation Oncology and Biophysics 20037 Washington, DC (USA)
  • | 2 Massachusetts Institute of Technology MIT Reactor Laboratory 02139 Cambridge MA (USA)
  • | 3 NASA-Lewis 44135 Cleveland OH (USA)
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Abstract  

The direct production of anhydrous13F ion has been achieved through the incorporation of a new approach to hot atom reactions for reactor generated radiopharmaceuticals. Capitalizing on the traditional Li2CO3 method for hydrated18F production, a unique target design and geometry utilizing neutron generated energetic tritions emerging from the surface of a thin LiF embedded stainless steel matrix react with gaseous O2 to produce18F as a free recoiling anhydrous species. Approximately 10–15 MBq of reactive anhydrous18F ion absorbed onto a metallic foil has been produced by this method. Verification of the production of18F was substantiated through decay measurements using Ge(Li) spectroscopic analysis, and by the synthesis of18F-fluoromethane gas. Cyclotron gas target chemistry which has been instrumental in the preparation of18F-2FDG and other metabolic tracers may be reproduced using this technique by the addition of 1% F2 scavenger gas to a recirculating reactor gas handling system.

Manuscript Submission: HERE

  • Impact Factor (2019): 1.137
  • Scimago Journal Rank (2019): 0.360
  • SJR Hirsch-Index (2019): 65
  • SJR Quartile Score (2019): Q3 Analytical Chemistry
  • SJR Quartile Score (2019): Q3 Health, Toxicology and Mutagenesis
  • SJR Quartile Score (2019): Q2 Nuclear Energy and Engineering
  • SJR Quartile Score (2019): Q3 Pollution
  • SJR Quartile Score (2019): Q3 Public Health, Environmental and Occupational Health
  • SJR Quartile Score (2019): Q3 Radiology, Nuclear Medicine and Imaging
  • SJR Quartile Score (2019): Q3 Spectroscopy
  • Impact Factor (2018): 1.186
  • Scimago Journal Rank (2018): 0.408
  • SJR Hirsch-Index (2018): 60
  • SJR Quartile Score (2018): Q2 Nuclear Energy and Engineering
  • SJR Quartile Score (2018): Q2 Pollution

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Journal of Radionalytical and Nuclear Chemistry
Language English
Size A4
Year of
Foundation
1968
Volumes
per Year
4
Issues
per Year
12
Founder Akadémiai Kiadó
Founder's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher Akadémiai Kiadó
Springer Nature Switzerland AG
Publisher's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible
Publisher
Chief Executive Officer, Akadémiai Kiadó
ISSN 0236-5731 (Print)
ISSN 1588-2780 (Online)