Journal of Thermal Analysis and Calorimetry
Volume/Issue:
Volume 100: Issue 1
Thermal characterization of the solid state and raw material fluconazole by thermal analysis and pyrolysis coupled to GC/MS
Authors:
Elisana Moura Federal University of Pernambuco—UFPE Pharmaceutical Sciences Department Artur de Sá Avenue, Cidade Universitária 740-521 Recife PE Brazil

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Lidiane Correia Federal University of Pernambuco—UFPE Pharmaceutical Sciences Department Artur de Sá Avenue, Cidade Universitária 740-521 Recife PE Brazil

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Márcia Pinto Federal University of Pernambuco—UFPE Pharmaceutical Sciences Department Artur de Sá Avenue, Cidade Universitária 740-521 Recife PE Brazil

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José Procópio Federal University of Pernambuco—UFPE Pharmaceutical Sciences Department Artur de Sá Avenue, Cidade Universitária 740-521 Recife PE Brazil

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Fábio de Souza Federal University of Parahyba—UFPB Unified Laboratories of Medicine Development and Assay—LUDEM Campos I 58059-900 João Pessoa PB Brazil

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Rui Macedo

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Pages:
289–293
Online Publication Date:
18 Sep 2009
Publication Date:
01 Apr 2010
Article Category:
Research Article
DOI:
https://doi.org/10.1007/s10973-009-0473-x
Keywords:
Thermal analysis; Pyrolysis; Fluconazole
Restricted access

Abstract  

This article had studied the thermal characterization of the raw material and different fluconazole crystals, obtained through recrystallization with different solvents using thermoanalytical techniques (TG, DTA, DSC-50, DSC Photovisual, DSC-60) and Pyr-GC/MS. The results confirmed that the fluconazole volatilizes without decomposition until 250 °C. Pyr-GC/MS showed hexachlorobenzene like impurities in fluconazole raw material.

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Cover Journal of Thermal Analysis and Calorimetry
Journal of Thermal Analysis and Calorimetry
Print ISSN:
1388-6150
Online ISSN:
1572-8943

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Journal of Thermal Analysis and Calorimetry
Language English
Size A4
Year of
Foundation		 1969
Volumes
per Year		 1
Issues
per Year		 24
Founder Akadémiai Kiadó
Founder's
Address		 H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher Akadémiai Kiadó
Springer Nature Switzerland AG
Publisher's
Address		 H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible
Publisher		 Chief Executive Officer, Akadémiai Kiadó
ISSN 1388-6150 (Print)
ISSN 1588-2926 (Online)

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