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  • 1 Chinese Academy of Sciences Materials and Thermochemistry Laboratory, Dalian Institute of Chemical Physics 457 Zhongshan Road Dalian 116023 People’s Republic of China
  • | 2 Zunyi Normal College Department of Chemistry Zunyi 563002 People’s Republic of China
  • | 3 Liaoning Normal University College of Chemistry and Chemical Engineering Dalian 116029 China
  • | 4 Chinese Academy of Sciences Division of Biotechnology, Dalian Institute of Chemical Physics 457 Zhongshan Road Dalian 116023 People’s Republic of China
  • | 5 Dalian Institute of Drug Detection Dalian 116021 People’s Republic of China
  • | 6 Sony Corporation, Institute of Higher Education Kanagawa 2438501 Japan
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Abstract  

The microcalorimetric method has been used to study the effects of cefpiramide and ceftizoxime sodium on the E. coli growth. The results revealed that these two cephalosporins may alter the metabolic way of the E. coli. Moreover, the lethal doses of cefpiramide and ceftizoxime sodium are 2.000 and 0.2000 μg mL−1, respectively. Combining with the relationships between growth rate constant (k), the maximum power output (P m), the time corresponding to the maximum power output (t m) and cephalosporins concentration (C), one can draw the conclusion that the ceftizoxime sodium has a stronger inhibition effects on the growth of E. coli than that of cefpiramide and they both have the possibility to induce the drug fever.