Journal of Thermal Analysis and Calorimetry
Volume/Issue:
Volume 100: Issue 3
DSC and spectroscopic investigation of human serum albumin adsorbed onto silica nanoparticles functionalized by amino groups
Authors:
Elena Parfenyuk Institution of Russian Academy of Sciences Institute of Solution Chemistry of the RAS Ivanovo Russia

Search for other papers by Elena Parfenyuk in
Current site
Google Scholar
PubMed Close
,
Galina Kulikova Institution of Russian Academy of Sciences Institute of Solution Chemistry of the RAS Ivanovo Russia

Search for other papers by Galina Kulikova in
Current site
Google Scholar
PubMed Close
, and
Irina Ryabinina Institution of Russian Academy of Sciences Institute of Solution Chemistry of the RAS Ivanovo Russia

Search for other papers by Irina Ryabinina in
Current site
Google Scholar
PubMed Close
Pages:
987–991
Online Publication Date:
01 Dec 2009
Publication Date:
01 Jun 2010
Article Category:
Research Article
DOI:
https://doi.org/10.1007/s10973-009-0604-4
Keywords:
DSC; Human serum albumin; Modified silica nanoparticles temperature of denaturation transition; Structural alterations
Restricted access

Abstract  

Human serum albumin (HSA) adsorbed onto silica nanoparticles modified by 3-aminopropyltriethoxysilane (APTES) and polyethyleneimine (PEI) was investigated by differential scanning calorimetry, IR spectroscopy, and photon correlation spectroscopy. The structural alterations of the protein molecules induced from adsorption process were estimated on the basis of temperatures of denaturation transition (Td) of the protein in free (native) and adsorbed form. It was found that adsorption of the protein onto the APTES-modified silica nanoparticles results in an increase in the temperature of denaturation transition from 42 to 47.4 °C. HSA adsorbed onto the PEI-modified silica nanoparticles unfolds extensively.

  • Collapse
  • Expand
Cover Journal of Thermal Analysis and Calorimetry
Journal of Thermal Analysis and Calorimetry
Print ISSN:
1388-6150
Online ISSN:
1572-8943

To see the editorial board, please visit the website of Springer Nature.

Manuscript Submission: HERE

For subscription options, please visit the website of Springer Nature.

Journal of Thermal Analysis and Calorimetry
Language English
Size A4
Year of
Foundation		 1969
Volumes
per Year		 1
Issues
per Year		 24
Founder Akadémiai Kiadó
Founder's
Address		 H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher Akadémiai Kiadó
Springer Nature Switzerland AG
Publisher's
Address		 H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible
Publisher		 Chief Executive Officer, Akadémiai Kiadó
ISSN 1388-6150 (Print)
ISSN 1588-2926 (Online)

Monthly Content Usage

Abstract Views Full Text Views PDF Downloads
Aug 2024 7 0 0
Sep 2024 14 0 0
Oct 2024 33 0 0
Nov 2024 6 0 0
Dec 2024 2 0 0
Jan 2025 14 1 1
Feb 2025 4 0 0