Authors:
Jian Wang Pharmacy College, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137 People’s Republic of China

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Danhong Cheng

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Nan Zeng Pharmacy College, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137 People’s Republic of China

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Houlin Xia Pharmacy College, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137 People’s Republic of China

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Yong Fu Pharmacy College, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137 People’s Republic of China

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Dan Yan China Military Institute of Chinese Materia Medica, 302 Military Hospital of China, Beijing, 100039 People’s Republic of China

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Yanling Zhao China Military Institute of Chinese Materia Medica, 302 Military Hospital of China, Beijing, 100039 People’s Republic of China

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Xiaohe Xiao China Military Institute of Chinese Materia Medica, 302 Military Hospital of China, Beijing, 100039 People’s Republic of China

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Abstract  

A useful microcalorimetric technique based on the bacterial heat production was applied to evaluate the antibacterial effects of Benzoinum and Styrax on the growth of Staphylococcus aureus (S. aureus). The thermogenic power-time curves of S. aureus growth in the presence of the two drugs were determined by a thermal activity monitor (TAM) air isothermal microcalorimeter, ampoule mode, at 310 K. Some quantitative metabolic parameters, such as growth rate constant k, the heat-flow power P, the appearance time for the heat power t, and the heat production Q were obtained from these curves. By analyzing these curves and some quantitative parameters using principal component analysis (PCA), the antibacterial effects of Benzoinum and Styrax on S. aureus growth were accurately evaluated from the change of the two main parameters, the heat-flow power for the second peaks P2nd and total heat production Qt: the antibacterial effects of the two drugs at concentrations of 0–125 mg mL−1 were both enhanced with increasing the concentration, and Benzoinum with IC50 of 132.2 mg mL−1 had stronger antibacterial effect than Styrax with IC50 of 179.8 mg mL−1. This study provides some useful references for the application of Benzoinum and Styra as potential antibacterial agents. Microcalorimetry is a powerful analytical tool for the characterization of the microbial growth progress and the evaluation of the drugs’ efficiency.

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Journal of Thermal Analysis and Calorimetry
Language English
Size A4
Year of
Foundation
1969
Volumes
per Year
1
Issues
per Year
24
Founder Akadémiai Kiadó
Founder's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher Akadémiai Kiadó
Springer Nature Switzerland AG
Publisher's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible
Publisher
Chief Executive Officer, Akadémiai Kiadó
ISSN 1388-6150 (Print)
ISSN 1588-2926 (Online)

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