Authors:
,
,
,
,
,
, and
Z. Aigner
Z. Aigner
Department of Pharmaceutical Technology, University of Szeged, Eötvös u. 6, Szeged H-6720, Hungary
Search for other papers by Z. Aigner in
Current site
Google Scholar
PubMed
Search for other papers by Z. Aigner in
Current site
Google Scholar
PubMed
R. Heinrich
R. Heinrich
Department of Pharmaceutical Technology, University of Medicine and Pharmacy of Târgu Mures, Marinescu Str. 38, 540139, Targu-Mures, Romania
Search for other papers by R. Heinrich in
Current site
Google Scholar
PubMed
Search for other papers by R. Heinrich in
Current site
Google Scholar
PubMed
E. Sipos
E. Sipos
Department of Pharmaceutical Technology, University of Medicine and Pharmacy of Târgu Mures, Marinescu Str. 38, 540139, Targu-Mures, Romania
Search for other papers by E. Sipos in
Current site
Google Scholar
PubMed
Search for other papers by E. Sipos in
Current site
Google Scholar
PubMed
G. Farkas
G. Farkas
Department of Pharmaceutical Technology, University of Szeged, Eötvös u. 6, Szeged H-6720, Hungary
Search for other papers by G. Farkas in
Current site
Google Scholar
PubMed
Search for other papers by G. Farkas in
Current site
Google Scholar
PubMed
A. Ciurba
A. Ciurba
Department of Pharmaceutical Technology, University of Medicine and Pharmacy of Târgu Mures, Marinescu Str. 38, 540139, Targu-Mures, Romania
Search for other papers by A. Ciurba in
Current site
Google Scholar
PubMed
Search for other papers by A. Ciurba in
Current site
Google Scholar
PubMed
O. Berkesi
O. Berkesi
Department of Physical Chemistry and Materials Science, University of Szeged, Aradi Vértanúk tere 1, Szeged H-6720, Hungary
Search for other papers by O. Berkesi in
Current site
Google Scholar
PubMed
Search for other papers by O. Berkesi in
Current site
Google Scholar
PubMed
P. Szabó-Révész
P. Szabó-Révész
Department of Pharmaceutical Technology, University of Szeged, Eötvös u. 6, Szeged H-6720, Hungary
Search for other papers by P. Szabó-Révész in
Current site
Google Scholar
PubMed
Search for other papers by P. Szabó-Révész in
Current site
Google Scholar
PubMed
Abstract
The compatibility of aceclofenac with various tableting excipients was investigated by means of differential scanning calorimetry (DSC) and Fourier transform infrared spectroscopy (FT-IR). The excipients applied in the direct pressing retard tablets were Carbopol 940, hydroxypropyl-methyl-cellulose, microcrystalline cellulose, Aerosil 200 and magnesium stearate. The ingredients alone and their 1:1 (w/w) binary mixtures were investigated before and after accelerated storage. An interaction was observed only between aceclofenac and magnesium stearate. The DSC and FT-IR examinations indicated formation of the magnesium salt of aceclofenac. For the other mixtures, there was no incompatibility between the components.
ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1. Thumma, S, Repka, MA. Compatibility studies of promethazine hydrochloride with tablet excipients by means of thermal and non-thermal methods. Pharmazie 2009 64:183–189.
-
2. Crowley, P, Martini, L. Drug-excipient interactions. Pharm Technol Eur 2001 13:26–34.
-
3. McDaid, FM, Barker, SA, Fitzpatrick, S, Petts, CR, Craig, DQM. Further investigations into the use of high sensitivity differential scanning calorimetry as a means of predicting drug–excipient interactions. Int J Pharm 2003 252:235–240 .
-
4. Kiss, D, Zelkó, R, Novák, Cs, Éhen, Zs. Application of DSC and NIRs to study the compatibility of metronidazole with different pharmaceutical excipients. J Therm Anal Calorim 2006 84:447–451 .
-
5. Mura, P, Manderioli, A, Bramanti, G, Furlanetto, S, Pinzauti, S. Utilization of differential scanning calorimetry as a screening technique to determine the compatibility of ketoprofen with excipients. Int J Pharm 1995 119:71–79 .
-
6. Rezende, RLO, Santoro, MIRM, Matos, JR. Stability and compatibility study on enalapril maleate using thermoanalytical techniques. J Therm Anal Calorim 2008 93:881–886 .
-
7. Araújo, AAS, Storpirtis, S, Mercuri, LP, Carvalho, FMS, Filho, MS, Matos, JR. Thermal analysis of the antiretroviral zidovudine (AZT) and evaluation of the compatibility with excipients used in solid dosage forms. Int J Pharm 2003 260:303–314 .
-
8. Zaccaron, CM, Oliveira, RVB, Guiotoku, M, Pires, ATN, Soldi, V. Blends of hydroxypropyl methylcellulose and poly(1-vinylpyrrolidone-co-vinyl acetate): miscibility and thermal satibility. Polym Degrad Stab 2005 90:21–27 .
-
9. Schmitt, EA, Peck, K, Sun, Y, Geoffroy, J-M. Rapid, practical and predictive excipient compatibility screening using isothermal microcalorimetry. Thermochim Acta 2001 380:175–183 .
-
10. Verma, RK, Garg, S. Selection of excipients for extended release formulations of glipizide through drug–excipient compatibility testing. J Pharm Biomed Anal 2005 38:633–644 .
-
11. Hasan, NY, Abdel-Elkawy, M, Elzeany, BE, Wagieh, NE. Stability indicating methods for the determination of aceclofenac. Il Farmaco 2003 48:91–99 .
-
12. Chopra, D, Sinha, VR, Singh, M. Thermal and isothermal methods in development of sustained release dosage forms of ketorolac tromethamine. J Chem 2008 5:316–322.
-
13. Mutalik, S, Naha, A, Usha, AN, Ranjith, AK, Musmade, P, Manoj, K, Anju, P, Prasanna, S. Preparation, in vitro, preclinical and clinical evaluations of once daily sustained release tablets of aceclofenac. Arch Pharm Res 2007 30:222–234 .
-
14. Parfitt, K. Analgesics, anti-inflammatory and antipyretics 1999 Reynolds, JEF eds. Martindale the complete drug reference 32 Pharmaceutical Press London 2–12.
-
15. Burrull, M, Madridejos, R, Gregori, A, Busquets, E. Non-steroid anti-inflammatory agents and gastrointestinal protection: adequate prescription in primary care?. Aten Primaria 1996 18:507–510.
-
16. Mutalik, S, Anju, P, Manoj, K, Usha, AN. Enhancement of dissolution rate and bioavailability of aceclofenac: a chitosan-based solvent change approach. Int J Pharm 2008 351:279–290 .
-
17. Tran, TT-D, Tran, PH-L, Lee, B-J. Dissolution–modulating mechanism of alkalizers and polymers in a nanoemulsifying solid dispersion containing ionizable and poorly water-soluble drug. Eur J Pharm Biopharm 2009 72:83–90 .
-
18. Patel, AR, Joshi, VY. Evaluation of SLS: APG mixed surfactant systems as carrier for solid dispersion. AAPS Pharmscitech 2008 9:583–590 .
-
19. Vadher, AH, Parikh, JR, Parikh, RH, Solanki, AB. Preparation and characterization of co-grinded mixtures of aceclofenac and Neusilin US2 for dissolution enhancement of aceclofenac. AAPS Pharmscitech 2009 10:606–614 .
-
20. Ceschel, GC, Badiello, R, Ronchi, C, Maffei, P. Degradation of components in drug formulations: a comparison between HPLC and DSC methods. J Pharm Biomed Anal 2003 32:1067–1072 .
To see the editorial board, please visit the website of Springer Nature.
Manuscript Submission: HERE
For subscription options, please visit the website of Springer Nature.
| Journal of Thermal Analysis and Calorimetry | |
|---|---|
| Language | English |
| Size | A4 |
| Year of Foundation |
1969 |
| Volumes per Year |
1 |
| Issues per Year |
24 |
| Founder | Akadémiai Kiadó |
| Founder's Address |
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245. |
| Publisher | Akadémiai Kiadó Springer Nature Switzerland AG |
| Publisher's Address |
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245. CH-6330 Cham, Switzerland Gewerbestrasse 11. |
| Responsible Publisher |
Chief Executive Officer, Akadémiai Kiadó |
| ISSN | 1388-6150 (Print) |
| ISSN | 1588-2926 (Online) |
Monthly Content Usage
| Abstract Views | Full Text Views | PDF Downloads | |
|---|---|---|---|
| Nov 2024 | 58 | 0 | 0 |
| Dec 2024 | 21 | 0 | 0 |
| Jan 2025 | 50 | 0 | 0 |
| Feb 2025 | 70 | 0 | 0 |
| Mar 2025 | 58 | 0 | 0 |
| Apr 2025 | 21 | 0 | 0 |
| May 2025 | 10 | 0 | 0 |
Copyright Akadémiai Kiadó AKJournals is the trademark of Akadémiai Kiadó's journal publishing business branch.
Powered by PubFactory