Geopolymers
Inorganic polymeric new materials
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R. Ambrus
R. Ambrus
Department of Pharmaceutical Technology, University of Szeged, 6720, Eötvös u. 6, Szeged, Hungary
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Z. Aigner
Z. Aigner
Department of Pharmaceutical Technology, University of Szeged, 6720, Eötvös u. 6, Szeged, Hungary
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L. Catenacci
L. Catenacci
Department of Pharmaceutical Chemistry, University of Pavia, Via Taramelli 12, 27100, Pavia, Italy
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G. Bettinetti
G. Bettinetti
Department of Pharmaceutical Chemistry, University of Pavia, Via Taramelli 12, 27100, Pavia, Italy
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P. Szabó-Révész
P. Szabó-Révész
Department of Pharmaceutical Technology, University of Szeged, 6720, Eötvös u. 6, Szeged, Hungary
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M. Sorrenti
M. Sorrenti
Department of Pharmaceutical Chemistry, University of Pavia, Via Taramelli 12, 27100, Pavia, Italy
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Abstract
In view of the poor aqueous solubility of nifluminic acid (NIF), the aim of this article was to improve its solubility and dissolution rate through the preparation of formulations based on hydroxypropyl β-cyclodextrin (HPβCD) and polyvinylpyrrolidone K25 (PVP K25), a combination of carriers which has been advantageously used for a similar purpose with various hydrophobic drugs. Ternary systems of NIF, HPβCD, and PVP K25 were prepared in different drug to CD to PVP ratios by physical mixing, kneading, microwave irradiation, and co-evaporation. Differential scanning calorimetry, thermogravimetric analysis, hot stage microscopy, Fourier transform infrared spectroscopy, and X-ray powder diffractometry were used to investigate the resulting solid-state interactions. The results showed that the solid state of the drug in the amorphous or crystalline ternary combinations influenced both the solubility and the dissolution rate of NIF.
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| Journal of Thermal Analysis and Calorimetry | |
|---|---|
| Language | English |
| Size | A4 |
| Year of Foundation |
1969 |
| Volumes per Year |
1 |
| Issues per Year |
24 |
| Founder | Akadémiai Kiadó |
| Founder's Address |
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245. |
| Publisher | Akadémiai Kiadó Springer Nature Switzerland AG |
| Publisher's Address |
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245. CH-6330 Cham, Switzerland Gewerbestrasse 11. |
| Responsible Publisher |
Chief Executive Officer, Akadémiai Kiadó |
| ISSN | 1388-6150 (Print) |
| ISSN | 1588-2926 (Online) |
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Temperature dependence of the rate of reaction in thermal analysis
The Arrhenius equation in condensed phase kinetics
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