Geopolymers
Inorganic polymeric new materials
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Senthilkumar Sivaprakasam
Senthilkumar Sivaprakasam
Laboratory of Integrated Bioprocessing (LiB), School of Biotechnology, Dublin City University, Dublin 9, Ireland
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Moira Monika Schuler
Moira Monika Schuler
Laboratory of Integrated Bioprocessing (LiB), School of Biotechnology, Dublin City University, Dublin 9, Ireland
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Adel Hama
Adel Hama
Laboratory of Integrated Bioprocessing (LiB), School of Biotechnology, Dublin City University, Dublin 9, Ireland
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Katie-Marie Hughes
Katie-Marie Hughes
Laboratory of Integrated Bioprocessing (LiB), School of Biotechnology, Dublin City University, Dublin 9, Ireland
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Ian W. Marison
Ian W. Marison
Laboratory of Integrated Bioprocessing (LiB), School of Biotechnology, Dublin City University, Dublin 9, Ireland
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Abstract
Control of bioprocesses requires reliable and robust on- or in-line monitoring tools providing real-time information on process dynamics. Heat generation related to metabolic activity of living systems is currently gaining importance in bioprocess industry due to its non-invasive and essentially instantaneous characteristics. This study deals with monitoring and control of pure aerobic fed-batch cultures of three Crabtree-negative yeast strains, Kluyveromyces marxianus, Candida utilis and Pichia pastoris, based on in-line measured, metabolic heat flow signals. A high resolution biocalorimeter (BioRC1) was developed from a standard bench-scale heat flow calorimeter (RC1). The BioRC1 was equipped with in-line (dielectric spectroscopy, pH probe and dissolved oxygen probe) and at-line (exit gas analyser) sensors to characterise the growth behaviour of the yeast cells. Both metabolic heat flow and biomass profiles exhibited similar behaviour proving the significance of employing heat flow signal as a key-parameter for the system under investigation. A simple estimator for biomass concentration and specific growth rate was formulated based on heat flow values. In order to evaluate the potential of calorimetry as a reliable and powerful process monitoring tool, the robustness, reliability as well as the broad applicability of the developed estimators was assessed through comparison with off-line measurement techniques and showed promising results for general applicability with a wide range of bioprocesses.
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| Journal of Thermal Analysis and Calorimetry | |
|---|---|
| Language | English |
| Size | A4 |
| Year of Foundation |
1969 |
| Volumes per Year |
1 |
| Issues per Year |
24 |
| Founder | Akadémiai Kiadó |
| Founder's Address |
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245. |
| Publisher | Akadémiai Kiadó Springer Nature Switzerland AG |
| Publisher's Address |
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245. CH-6330 Cham, Switzerland Gewerbestrasse 11. |
| Responsible Publisher |
Chief Executive Officer, Akadémiai Kiadó |
| ISSN | 1388-6150 (Print) |
| ISSN | 1588-2926 (Online) |
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Temperature dependence of the rate of reaction in thermal analysis
The Arrhenius equation in condensed phase kinetics
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