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  • 1 Microbiology Division, Central Leather Research Institute (Council of Scientific and Industrial Research), Adyar, Chennai 600020, Tamil Nadu, India
  • | 2 Chemical Laboratory, Central Leather Research Institute (Council of Scientific and Industrial Research), Adyar, Chennai 600020, Tamil Nadu, India
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Abstract

This study emphasizes, cross-linking potential of a simple di-carboxylic acid, namely, oxalic acid with type I collagen for the preparation of collagen based biomaterial for clinical applications. Further the study discusses the characteristics features of the cross-linked material in comparison with the standard cross-linker. In addition, the study also demonstrates the role of ionic interactions in providing the thermal stability and tensile strength to the cross-linked biopolymer material. Type I collagen from rat tail tendon treated with oxalic acid at optimized concentrations provided a biopolymer material without changing the triple helical pattern of collagen (CD spectrum) and also with 6–7 fold increase in tensile strength than native collagen. FTIR spectral details demonstrate the ionic interactions between collagen and oxalic acid. Thermal stability analyses of oxalic acid cross-linked biopolymer revealed, high thermal stability compared to materials of glutaraldehyde cross-linked. The results of the study suggest oxalic acid as a suitable cross-linker for collagen and it cross-link with collagen through ionic interactions.

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  • Impact Factor (2019): 2.731
  • Scimago Journal Rank (2019): 0.415
  • SJR Hirsch-Index (2019): 87
  • SJR Quartile Score (2019): Q3 Condensed Matter Physics
  • SJR Quartile Score (2019): Q3 Physical and Theoretical Chemistry
  • Impact Factor (2018): 2.471
  • Scimago Journal Rank (2018): 0.634
  • SJR Hirsch-Index (2018): 78
  • SJR Quartile Score (2018): Q2 Condensed Matter Physics
  • SJR Quartile Score (2018): Q2 Physical and Theoretical Chemistry

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Journal of Thermal Analysis and Calorimetry
Language English
Size A4
Year of
Foundation
1969
Volumes
per Year
4
Issues
per Year
24
Founder Akadémiai Kiadó
Founder's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher Akadémiai Kiadó
Springer Nature Switzerland AG
Publisher's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible
Publisher
Chief Executive Officer, Akadémiai Kiadó
ISSN 1388-6150 (Print)
ISSN 1588-2926 (Online)

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