View More View Less
  • 1 Department of Inorganic Chemistry, Faculty of Chemistry, University of Bucharest, 90-92Panduri Str., Sector 5, 050663, Bucharest, Romania
  • | 2 Institute for Control of Biological Products and Veterinary Medicines, 39 Dudului, Sector 6, Bucharest, Romania
Restricted access

Abstract

Novel complexes of type [M2LCl4nH2O ((1) M:Ni, n = 5; (2) M:Cu, n = 0 and (3) M:Zn, n = 2; L: ligand resulted from 1,2-phenylenediamine, 3,6-diazaoctane-1,8-diamine and formaldehyde template condensation) were synthesised and characterised. The features of complexes have been assigned from microanalytical, IR and UV–Vis data. The thermal analyses have evidenced the thermal intervals of stability and also the thermodynamic effects that accompany them. Processes as water or hydrochloric acid elimination as well as oxidative degradation of the organic ligand were observed. Complexes display a different thermal behaviour as result of dissimilar chemical interaction of metal ions with chloride anions. The final product of decomposition was metal(II) oxide as powder X-ray diffraction indicated.

  • 1. M Gielen RT Tiekink eds. 2005 Metallotherapeutic drugs and metal-based diagnostic agents. The use of metals in medicine Wiley Chichester, England.

    • Search Google Scholar
    • Export Citation
  • 2. Schols, D, Esté, JA, Henson, G E De Clercq 1997 Bicyclams, a class of potent anti-HIV agents, are targeted at the HIV coreceptor fusin/CXCR-4. Antiviral Res 35:147156 .

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 3. Gerlach, LO, Skerlj, RT, Bridger, GJ, Schwartz, TW 2001 Molecular interactions of cyclam and bicyclam non-peptide antagonists with the CXCR4 chemokine receptor. J Biol Chem 276:1415314160 .

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 4. Liang, X, Sadler, PJ 2004 Cyclam complexes and their applications in medicine. Chem Soc Rev 33:246266 .

  • 5. Fricker, SP, Anastassov, V, Cox, J, Darkes, MC, Grujic, O, Idzan, SR, Labrecque, J, Lau, G, Mosi, RM, Nelson, KL, Qin, L, Santucci, Z, Wong, RSY 2006 Characterization of the molecular pharmacology of AMD3100: a specific antagonist of the G-protein coupled chemokine receptor, CXCR4. Biochem Pharmacol 72:588596 .

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 6. E De Clercq 2000 Inhibition of HIV infection by bicyclams, highly potent and specific CXCR4 antagonists. Mol Pharmacol 57:833839.

  • 7. Liang, X, Parkinson, JA, Weishäupl, M, Gould, RO, Paisey, SJ, Park, H-S, Hunter, TM, Blindauer, CA, Parsons, S, Sadler, PJ 2002 Structure and dynamics of metallomacrocycles: recognition of zinc xylyl-bicyclam by an HIV coreceptor. J Am Chem Soc 124:91059112 .

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 8. Valks, GC, McRobbie, G, Lewis, EA, Hubin, TJ, Hunter, TM, Sadler, PJ, Pannecouque, C E De Clercq Archibald, SJ 2006 Configurationally restricted bismacrocyclic CXCR4 receptor antagonists. J Med Chem 49:61626165 .

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 9. Affani, R, Pélissier, F, Aubertin, A-M, Dugat, D 2009 Bis-14-membered ring diketal diamines: synthesis and evaluation of their anti-HIV and anti-tumoral activities. Eur J Med Chem 44:31383146 .

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 10. Arjmand, F, Aziz, M 2009 Synthesis and biophysical studies of bis-macrocyclic cobalt/copper(II) complexes having a pyridine spacer with CT DNA and 5′-GMP. Chem Biodivers 6:22752289 .

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 11. Kang, S-G, Ryu, K, Suh, MP, Jeong, JH 1997 Template synthesis and crystal structure of a novel mononuclear nickel(II) complex with a face-to-face bis(macrocyclic) ligand. Inorg Chem 36:24782481 .

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 12. Kang, S-G, Song, J, Jeong, JH 2004 Synthesis and characterization of new unsaturated macrobicyclic and bis(macrocyclic) copper(II) complexes containing N–CH2–N linkages. Inorg Chim Acta 357:605610 .

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 13. Salavati-Niasari, M, Bazarganipour, M 2006 Bis(macrocyclic) copper(II) complexes containing aromatic nitrogen–nitrogen linkers produced by in situ one pot template condensation reaction (IOPTCR): synthesis, characterization and catalytic oxidation of tetrahydrofuran. Inorg Chem Commun 9:332336 .

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 14. Chandra, S, Jain, D, Ratnam, B 2010 Synthesis and spectroscopic characterization of copper (II) metal complexes of a 16 membered pentaaza (N5) bis (macrocyclic) complexes. J Chem Pharm Res 2:533538.

    • Search Google Scholar
    • Export Citation
  • 15. Olar, R, Badea, M, Stanica, N, Cristurean, E, Marinescu, D 2005 Synthesis, characterisation and thermal behaviour of some complexes with ligands having 1,3,4-thiadiazole moieties. J Therm Anal Calorim 82:417422 .

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 16. Olar, R, Badea, M, Marinescu, D, Lazar, V, Chifiriuc, C 2009 Thermal behaviour of new Ni(II) and Cu(II) complexes with macrocyclic ligands functionalised with 1,2,4-triazole. J Therm Anal Calorim 97:315321 .

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 17. Salavati-Niasari, M, Amiri, A 2005 Binuclear copper(II) complexes of new bis(macrocyclic) 16-membered pentaaza subunits are linked together by bridging nitrogen of amine: synthesis, characterization and catalytic activity. J Mol Catal A 235:114121 .

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 18. Nakamoto, K 1986 Infrared and Raman spectra of inorganic and coordination compounds Wiley New York 228229.

  • 19. Lever ABP . Inorganic electronic spectroscopy. Amsterdam, London, New York: Elsevier; 1986. p. 53442, 560-7.

  • 20. Olar, R, Badea, M, Marinescu, D 2010 Thermal study of some new Ni(II) and Cu(II) complexes with ligands derived from N,N-dimethylbiguanide as potential antimicrobials. J Therm Anal Calorim 99:893898 .

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 21. Mészáros Szécsényi K , Leovac VM, Kovács A, Pokol G, Jaćimović K. Transition metal complexes with pyrazole-based ligands Part 21. Thermal decomposition of copper and cobalt halide complexes with 3,5-dimethyl-1-thiocarboxamidepyrazole. J Therm Anal Calorim. doi: .

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 22. Dziewulska-Kułaczkowska, A, Mazur, L, Ferenc, W 2009 Thermal, spectroscopic and structural studies of Zn(II) complex with nicotinamide. J Therm Anal Calorim 96:255260 .

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 23. Köse, DA, Gökçe, G, Gökçeand, S, Uzun, I 2009 Bis(N,N-diethylnicotinamide) p-chlorobenzoate complexes of Ni(II), Zn(II) and Cd(II). Synthesis and characterization. J Therm Anal Calorim 95:247251 .

    • Crossref
    • Search Google Scholar
    • Export Citation