Journal of Thermal Analysis and Calorimetry
Volume/Issue:
Volume 105: Issue 2
Thermal analysis study of amlodipine as pure compound and in binary mixture
Authors:
Corina Duda-Seiman Research Center for Thermal Analysis in Environmental Problems, West University of Timisoara, Pestalozzi Street 16, 300115, Timisoara, Romania

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T. Vlase Research Center for Thermal Analysis in Environmental Problems, West University of Timisoara, Pestalozzi Street 16, 300115, Timisoara, Romania

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Gabriela Vlase Research Center for Thermal Analysis in Environmental Problems, West University of Timisoara, Pestalozzi Street 16, 300115, Timisoara, Romania

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D. Duda-Seiman University of Medicine and Pharmacy “Victor Babeş”, Eftimie Murgu Square 2, 300041, Timisoara, Romania

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P. Albu Research Center for Thermal Analysis in Environmental Problems, West University of Timisoara, Pestalozzi Street 16, 300115, Timisoara, Romania

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N. Doca Research Center for Thermal Analysis in Environmental Problems, West University of Timisoara, Pestalozzi Street 16, 300115, Timisoara, Romania

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Pages:
677–683
Online Publication Date:
27 Mar 2011
Publication Date:
01 Aug 2011
Article Category:
Research Article
DOI:
https://doi.org/10.1007/s10973-011-1431-y
Keywords:
Amlodipine; Thermal behavior; Evolved gas analysis; Kinetics; NPK method
Restricted access

Abstract

Amlodipine is a very used selective calcium antagonist. The evaluation of thermal stability is crucial for the formulation setting of a solid dosage form. By heating in air under non-isothermal conditions, amlodipine presents two characteristic steps. More details were obtained using IR spectrometric data of the pure compound of the char, respectively, of the evolved gases at those temperatures. Data on a possible interaction between amlodipine and some excipients used in solid dosage forms were obtained by comparison of TG/DTG/DTA curves of amlodipine and of its mixtures with talc (considered thermally inert), magnesium stearate, starch and cellulose. No thermally induced interactions were observed. In order to obtain data for a believable Life Time Prediction a kinetic analysis was performed. The data of the first step of mass loss obtained at four heating rates (7, 10, 12, and 15 °C min−1, respectively) were processed using at least three different methods. From these, the NPK method seems to be adequate because the separation between the temperature, respective the conversion dependent part of the reaction rate equation and the expression of the formal kinetic equation were obtained in a less speculative manner.

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Cover Journal of Thermal Analysis and Calorimetry
Journal of Thermal Analysis and Calorimetry
Print ISSN:
1388-6150
Online ISSN:
1572-8943

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Journal of Thermal Analysis and Calorimetry
Language English
Size A4
Year of
Foundation		 1969
Volumes
per Year		 1
Issues
per Year		 24
Founder Akadémiai Kiadó
Founder's
Address		 H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher Akadémiai Kiadó
Springer Nature Switzerland AG
Publisher's
Address		 H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible
Publisher		 Chief Executive Officer, Akadémiai Kiadó
ISSN 1388-6150 (Print)
ISSN 1588-2926 (Online)

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