Journal of Thermal Analysis and Calorimetry
Volume/Issue:
Volume 105: Issue 3
Thermal behavior of verapamil in pure and in solid dosage forms
Authors:
Corina Duda-Seiman Research Center for Thermal Analysis in Environmental Problems, West University of Timisoara, Pestalozzi Street 16, 300115, Timisoara, Romania

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T. Vlase Research Center for Thermal Analysis in Environmental Problems, West University of Timisoara, Pestalozzi Street 16, 300115, Timisoara, Romania

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Gabriela Vlase Research Center for Thermal Analysis in Environmental Problems, West University of Timisoara, Pestalozzi Street 16, 300115, Timisoara, Romania

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Rodica Cinca Faculty of Pharmacy, University of Medicine and Pharmacy “Victor Babeş”, Eftimie Murgu Square 2, 300041, Timişoara, Romania

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Mariana Anghel Department of Epidemiology, University of Medicine and Pharmacy “Victor Babeş”, Eftimie Murgu Square 2, 300041, Timişoara, Romania

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N. Doca Research Center for Thermal Analysis in Environmental Problems, West University of Timisoara, Pestalozzi Street 16, 300115, Timisoara, Romania

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Pages:
851–858
Online Publication Date:
01 Jul 2011
Publication Date:
01 Sep 2011
Article Category:
Research Article
DOI:
https://doi.org/10.1007/s10973-011-1460-6
Restricted access

Abstract

Verapamil is a phenyl-alchil-amine type pharmaceutical largely used as a specific calcium antagonist. Knowledge of drug-excipient compatibility represents an important phase in development of different dosage forms. Hyphenated techniques are versatile for obtaining such necessary information’s. The TG/DTG/DTA curves were obtained in air at different heating rates and in nitrogen. The IR spectra of pure compound and its char at 400 °C (by U-ATR technique) and the IR identification of Evolved Gasses allowed some discussions on the thermally induced events. In the solid dosage forms verapamil was mixed with talc, magnesium stearate, starch, and cellulose, and the corresponding thermoanalytical curves were compared with that one of pure I. No physical or chemical interactions were observed till 250 °C. A kinetic analysis was performed for TG step of verapamil between 250 and 350 °C. The data at four heating rates (7, 10, 12, 15 °C min−1) were processed on a strategy using at last three different kinetic methods. For these, the NPK method seems to be less speculative, allowing an objective determination of the kinetic parameters.

  • 1. Peck, TE, Hill, SA, Williams, M. Pharmacology for anesthesia and intensive care. 3 Cambridge: Cambridge Univ Press; 2008 .

  • 2. Chann, GF, Sever, PS, Hughes, AD. Calcium channel regulation in vascular smooth muscle cells: synergistic effect of stains and calcium channel blockers. Int J Cardiol. 2010;139:2 .

    • Crossref
    • Search Google Scholar
    • Export Citation

  • 3. Bagger, JP, Helisoe, P, Randsback, F, Kimose, HH, Jensen, BS. Effect of verapamil in intermittent claudication. Circulation. 1997;95:411.

    • Search Google Scholar
    • Export Citation

  • 4. Das, R, Burke, T, Van Wagner, DR, Plow, EF. L-type calcium channel blockers exert an antiinflamatory effect by suppressing expression of plasminogen receptors on macrophages. Circ Res. 2009;105:167 .

    • Crossref
    • Search Google Scholar
    • Export Citation

  • 5. Tomassetti, M, Catalani, A, Rossi, V, Vecchio, S. Thermal analysis study of interactions between acetaminophen and excipients in solid dosage forms and in some binary mixtures. J Pharm Biomed Anal. 2005;37:949 .

    • Crossref
    • Search Google Scholar
    • Export Citation

  • 6. Fuliaş, A, Vlase, T, Vlase, G, Doca, N. Thermal behaviour of cephalexin in different mixtures. J Therm Anal Cal. 2010;99–3:987–992. .

  • 7. Cross, AD. Introduction to practical infra-red spectroscopy. London: Butterworths; 1960.

  • 8. Brown, ME, Maciejewski, M, Vyazovkin, S, Nomen, R, Sempere, J, Burnham, A, et al. Computational aspects of kinetic analysis: part A: the ICTAC kinetics project-data, methods and results. Thermochim Acta. 2000;355:125–143. .

    • Crossref
    • Search Google Scholar
    • Export Citation

  • 9. Friedman, HL. Kinetics of thermal degradation of char-foaming plastics from hermogravimetry: application to a phenolic resin. J Polymer Sci. 1965;6C:183–195.

    • Search Google Scholar
    • Export Citation

  • 10. Flynn, JH, Wall, LA. A quick, direct method for the determination of activation energy from thermogravimetric data. Polym Lett. 1966;4:323–328. .

    • Crossref
    • Search Google Scholar
    • Export Citation

  • 11. Ozawa, T. A new method of analyzing thermogravimetric data. Bull Chem Soc Jpn. 1965;38:1881–1886. .

  • 12. Vlase, T, Vlase, G, Birta, N, Doca, N. Comparative results of kinetic data obtained with different methods for complex decomposition steps. J Therm Anal Calorim. 2007;88:631–635. .

    • Crossref
    • Search Google Scholar
    • Export Citation

  • 13. Vlase, G, Vlase, T, Doca, N. Thermal behavior of some phenitoine pharmaceuticals. J Therm Anal Calorim. 2008;92:259–262. .

  • 14. Birta, N, Doca, N, Vlase, G, Vlase, T. Kinetic of sorbitol decomposition under non-isothermal conditions. J Therm Anal Calorim. 2008;92:635–638. .

    • Crossref
    • Search Google Scholar
    • Export Citation

  • 15. Vlase, T, Doca, N, Vlase, G, Bolcu, C, Borcan, F. Kinetics of non-isothermal decomposition of three IRGANOX-type antioxidants. J Therm Anal Calorim. 2008;92:15–18. .

    • Crossref
    • Search Google Scholar
    • Export Citation

  • 16. Fuliaş, A, Vlase, G, Vlase, T, Tiţa, B, Tiţa, D, Doca, N. Thermal study of cefoperazone monohydrate. Rev Rou Chim. 2010;55: 8 481–486.

    • Search Google Scholar
    • Export Citation

  • 17. Wall, ME. Singular value decomposition and principal component analysis Berrar, DP, Dubitzky, W, Granzow, M, eds. Apractical approach to microarray data analysis. 9 MA: Kluwer-Norwel; 2003 91–109. LANL LA-UR-02.

    • Crossref
    • Search Google Scholar
    • Export Citation

  • 18. Śestak, J, Berggren, G. Study of the kinetics of the mechanism of solid-state reactions at increasing temperatures. Thermochim Acta. 1971;3:1–12. .

    • Crossref
    • Search Google Scholar
    • Export Citation

  • 19. Nunes, RS, Semaan, FA, Riga, AT, Cavalheiro, ETG. Thermal behavior of verapamil hydrochloride and its association with excipients. J Therm Anal Calorim. 2009;97:349–353. .

    • Crossref
    • Search Google Scholar
    • Export Citation
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Cover Journal of Thermal Analysis and Calorimetry
Journal of Thermal Analysis and Calorimetry
Print ISSN:
1388-6150
Online ISSN:
1572-8943

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Journal of Thermal Analysis and Calorimetry
Language English
Size A4
Year of
Foundation		 1969
Volumes
per Year		 1
Issues
per Year		 24
Founder Akadémiai Kiadó
Founder's
Address		 H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher Akadémiai Kiadó
Springer Nature Switzerland AG
Publisher's
Address		 H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible
Publisher		 Chief Executive Officer, Akadémiai Kiadó
ISSN 1388-6150 (Print)
ISSN 1588-2926 (Online)

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