Authors:
José Lamartine Soares-Sobrinho Department of Pharmaceutical Sciences, Federal University of Pernambuco, Arthur de Sá, s/n, 50740-521, Recife, PE, Brazil
Core of Pharmaceutical Technology, Federal University of Piauí, Campus Universitário Ministro Petrônio Portella, s/n, 64049-550, Teresina, PI, Brazil

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Monica Felts de La Roca Soares Department of Pharmaceutical Sciences, Federal University of Pernambuco, Arthur de Sá, s/n, 50740-521, Recife, PE, Brazil
Core of Pharmaceutical Technology, Federal University of Piauí, Campus Universitário Ministro Petrônio Portella, s/n, 64049-550, Teresina, PI, Brazil

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Pedro José Rolim-Neto Core of Pharmaceutical Technology, Federal University of Piauí, Campus Universitário Ministro Petrônio Portella, s/n, 64049-550, Teresina, PI, Brazil

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Juan J. Torres-Labandeira Department of Pharmacy and Pharmaceutical Technology, Facultad de Farmacia, Universidad de Santiago de Compostela, 15782, Santiago de Compostela, Spain

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Abstract

Although not being the ideal drug due to its low solubility and high toxicity, the benznidazole is the drug currently chosen for Chagas disease treatment. The deep knowledge about the characteristics of the drug in addition to the knowledge of more effective vectorization techniques of drugs in pharmaceutical forms allows a faster and cheaper development of a new therapeutic alternative in comparison to the introduction of a new molecule in the treatment. The aim of this study is the characterization of inclusion complexes Benznidazole and cyclodextrins in solid state. The interactions between Benznidazole (BNZ) and β-cyclodextrins (β-CD) modified: randomly methylated β-CD (RMβCD) and sulfobutylether β-CD (SBβCD) were studied by differential scanning calorimetry (DSC), fourier transform-infrared spectroscopy, RAMAN, and scanning electron microscopy. The preparation of solid-state binary systems by different techniques, namely, kneading, evaporated, and freeze-drying. The results suggest the formation of inclusion complexes of the drug with both CDs types in solid state by the techniques which were used, based on physicochemical data of interaction compared to the drug or the CDs/drug physical mixture. Thus, the preparation technique played an important role in the BNZ and modified CDs.

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  • 21. Soares-Sobrinho, JL, Cunha-Filho, MSS, Rolim-Neto, PJ, Torres-Labandeira, JJ, Dacunha-Marinho, B 2008 Benznidazole. Acta Cryst E64:o634.

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Journal of Thermal Analysis and Calorimetry
Language English
Size A4
Year of
Foundation
1969
Volumes
per Year
1
Issues
per Year
24
Founder Akadémiai Kiadó
Founder's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher Akadémiai Kiadó
Springer Nature Switzerland AG
Publisher's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible
Publisher
Chief Executive Officer, Akadémiai Kiadó
ISSN 1388-6150 (Print)
ISSN 1588-2926 (Online)

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