Geopolymers
Inorganic polymeric new materials
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José Lamartine Soares-Sobrinho
José Lamartine Soares-Sobrinho
Department of Pharmaceutical Sciences, Federal University of Pernambuco, Arthur de Sá, s/n, 50740-521, Recife, PE, Brazil
Core of Pharmaceutical Technology, Federal University of Piauí, Campus Universitário Ministro Petrônio Portella, s/n, 64049-550, Teresina, PI, Brazil
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Core of Pharmaceutical Technology, Federal University of Piauí, Campus Universitário Ministro Petrônio Portella, s/n, 64049-550, Teresina, PI, Brazil
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Monica Felts de La Roca Soares
Monica Felts de La Roca Soares
Department of Pharmaceutical Sciences, Federal University of Pernambuco, Arthur de Sá, s/n, 50740-521, Recife, PE, Brazil
Core of Pharmaceutical Technology, Federal University of Piauí, Campus Universitário Ministro Petrônio Portella, s/n, 64049-550, Teresina, PI, Brazil
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Core of Pharmaceutical Technology, Federal University of Piauí, Campus Universitário Ministro Petrônio Portella, s/n, 64049-550, Teresina, PI, Brazil
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Pedro José Rolim-Neto
Pedro José Rolim-Neto
Core of Pharmaceutical Technology, Federal University of Piauí, Campus Universitário Ministro Petrônio Portella, s/n, 64049-550, Teresina, PI, Brazil
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Juan J. Torres-Labandeira
Juan J. Torres-Labandeira
Department of Pharmacy and Pharmaceutical Technology, Facultad de Farmacia, Universidad de Santiago de Compostela, 15782, Santiago de Compostela, Spain
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Abstract
Although not being the ideal drug due to its low solubility and high toxicity, the benznidazole is the drug currently chosen for Chagas disease treatment. The deep knowledge about the characteristics of the drug in addition to the knowledge of more effective vectorization techniques of drugs in pharmaceutical forms allows a faster and cheaper development of a new therapeutic alternative in comparison to the introduction of a new molecule in the treatment. The aim of this study is the characterization of inclusion complexes Benznidazole and cyclodextrins in solid state. The interactions between Benznidazole (BNZ) and β-cyclodextrins (β-CD) modified: randomly methylated β-CD (RMβCD) and sulfobutylether β-CD (SBβCD) were studied by differential scanning calorimetry (DSC), fourier transform-infrared spectroscopy, RAMAN, and scanning electron microscopy. The preparation of solid-state binary systems by different techniques, namely, kneading, evaporated, and freeze-drying. The results suggest the formation of inclusion complexes of the drug with both CDs types in solid state by the techniques which were used, based on physicochemical data of interaction compared to the drug or the CDs/drug physical mixture. Thus, the preparation technique played an important role in the BNZ and modified CDs.
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| Journal of Thermal Analysis and Calorimetry | |
|---|---|
| Language | English |
| Size | A4 |
| Year of Foundation |
1969 |
| Volumes per Year |
1 |
| Issues per Year |
24 |
| Founder | Akadémiai Kiadó |
| Founder's Address |
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245. |
| Publisher | Akadémiai Kiadó Springer Nature Switzerland AG |
| Publisher's Address |
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245. CH-6330 Cham, Switzerland Gewerbestrasse 11. |
| Responsible Publisher |
Chief Executive Officer, Akadémiai Kiadó |
| ISSN | 1388-6150 (Print) |
| ISSN | 1588-2926 (Online) |
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Temperature dependence of the rate of reaction in thermal analysis
The Arrhenius equation in condensed phase kinetics
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