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Carolina V. Barra
Carolina V. Barra
Departamento de Química Geral e Inorgânica, Instituto de Química de Araraquara, UNESP–Univ Estadual Paulista, P.O. Box 355, Araraquara, SP, 14801-970, Brazil
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Fillipe V. Rocha
Fillipe V. Rocha
Departamento de Química Geral e Inorgânica, Instituto de Química de Araraquara, UNESP–Univ Estadual Paulista, P.O. Box 355, Araraquara, SP, 14801-970, Brazil
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Adelino V. G. Netto
Adelino V. G. Netto
Departamento de Química Geral e Inorgânica, Instituto de Química de Araraquara, UNESP–Univ Estadual Paulista, P.O. Box 355, Araraquara, SP, 14801-970, Brazil
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B. Shimura
B. Shimura
Departamento de Química Geral e Inorgânica, Instituto de Química de Araraquara, UNESP–Univ Estadual Paulista, P.O. Box 355, Araraquara, SP, 14801-970, Brazil
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Regina C. G. Frem
Regina C. G. Frem
Departamento de Química Geral e Inorgânica, Instituto de Química de Araraquara, UNESP–Univ Estadual Paulista, P.O. Box 355, Araraquara, SP, 14801-970, Brazil
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Antonio E. Mauro
Antonio E. Mauro
Departamento de Química Geral e Inorgânica, Instituto de Química de Araraquara, UNESP–Univ Estadual Paulista, P.O. Box 355, Araraquara, SP, 14801-970, Brazil
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Iracilda Z. Carlos
Iracilda Z. Carlos
Departamento de Análises Clínicas, Faculdade de Ciências Farmacêuticas de Araraquara, UNESP–Univ Estadual Paulista, P.O. Box 502, Araraquara, SP, 14801-902, Brazil
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Sandra R. Ananias
Sandra R. Ananias
Departamento de Análises Clínicas, Faculdade de Ciências Farmacêuticas de Araraquara, UNESP–Univ Estadual Paulista, P.O. Box 502, Araraquara, SP, 14801-902, Brazil
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Marcela B. Quilles
Marcela B. Quilles
Departamento de Análises Clínicas, Faculdade de Ciências Farmacêuticas de Araraquara, UNESP–Univ Estadual Paulista, P.O. Box 502, Araraquara, SP, 14801-902, Brazil
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Abstract
The pyrazole ligand 3,5-dimethyl-4-iodopyrazole (HdmIPz) has been used to obtain a series of palladium(II) complexes (1–4) of the type [PdX2(HdmIPz)2] {X = Cl− (1); Br− (2); I− (3); SCN− (4)}. All compounds have been isolated, purified, and characterized by means of elemental analysis, IR spectroscopy, 1H and 13C{1H}-NMR experiments, differential thermal analysis (DTA), and thermogravimetry (TG). The TG/DTA curves showed that the compounds released ligands in the temperature range 137–605 °C, yielding metallic palladium as final residue. The complexes and the ligand together with cisplatin have been tested in vitro by MTT assay for their cytotoxicity against two murine cancer cell lines: mammary adenocarcinoma (LM3) and lung adenocarcinoma (LP07).
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| Journal of Thermal Analysis and Calorimetry | |
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