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  • 1 Departamento de Química Geral e Inorgânica, Instituto de Química de Araraquara, UNESP–Univ Estadual Paulista, P.O. Box 355, Araraquara, SP, 14801-970, Brazil
  • | 2 Departamento de Análises Clínicas, Faculdade de Ciências Farmacêuticas de Araraquara, UNESP–Univ Estadual Paulista, P.O. Box 502, Araraquara, SP, 14801-902, Brazil
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Abstract

The pyrazole ligand 3,5-dimethyl-4-iodopyrazole (HdmIPz) has been used to obtain a series of palladium(II) complexes (14) of the type [PdX2(HdmIPz)2] {X = Cl (1); Br (2); I (3); SCN (4)}. All compounds have been isolated, purified, and characterized by means of elemental analysis, IR spectroscopy, 1H and 13C{1H}-NMR experiments, differential thermal analysis (DTA), and thermogravimetry (TG). The TG/DTA curves showed that the compounds released ligands in the temperature range 137–605 °C, yielding metallic palladium as final residue. The complexes and the ligand together with cisplatin have been tested in vitro by MTT assay for their cytotoxicity against two murine cancer cell lines: mammary adenocarcinoma (LM3) and lung adenocarcinoma (LP07).

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  • SJR Quartile Score (2018): Q2 Condensed Matter Physics
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Journal of Thermal Analysis and Calorimetry
Language English
Size A4
Year of
Foundation
1969
Volumes
per Year
4
Issues
per Year
24
Founder Akadémiai Kiadó
Founder's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher Akadémiai Kiadó
Springer Nature Switzerland AG
Publisher's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible
Publisher
Chief Executive Officer, Akadémiai Kiadó
ISSN 1388-6150 (Print)
ISSN 1588-2926 (Online)

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