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Carolina V. Barra
Carolina V. Barra
Departamento de Química Geral e Inorgânica, Instituto de Química de Araraquara, UNESP-Univ Estadual Paulista, 355, Araraquara, SP, 14801-970, Brazil
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Fillipe V. Rocha
Fillipe V. Rocha
Departamento de Química Geral e Inorgânica, Instituto de Química de Araraquara, UNESP-Univ Estadual Paulista, 355, Araraquara, SP, 14801-970, Brazil
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Adelino V. G. Netto
Adelino V. G. Netto
Departamento de Química Geral e Inorgânica, Instituto de Química de Araraquara, UNESP-Univ Estadual Paulista, 355, Araraquara, SP, 14801-970, Brazil
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Regina C. G. Frem
Regina C. G. Frem
Departamento de Química Geral e Inorgânica, Instituto de Química de Araraquara, UNESP-Univ Estadual Paulista, 355, Araraquara, SP, 14801-970, Brazil
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Antonio E. Mauro
Antonio E. Mauro
Departamento de Química Geral e Inorgânica, Instituto de Química de Araraquara, UNESP-Univ Estadual Paulista, 355, Araraquara, SP, 14801-970, Brazil
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Iracilda Z. Carlos
Iracilda Z. Carlos
Departamento de Análises Clínicas, Faculdade de Ciências Farmacêuticas de Araraquara, UNESP-Univ Estadual Paulista, 502, Araraquara, SP, 14801-902, Brazil
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Sandra R. Ananias
Sandra R. Ananias
Departamento de Análises Clínicas, Faculdade de Ciências Farmacêuticas de Araraquara, UNESP-Univ Estadual Paulista, 502, Araraquara, SP, 14801-902, Brazil
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Marcela B. Quilles
Marcela B. Quilles
Departamento de Análises Clínicas, Faculdade de Ciências Farmacêuticas de Araraquara, UNESP-Univ Estadual Paulista, 502, Araraquara, SP, 14801-902, Brazil
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Abstract
This study describes the synthesis, IR, 1H, and 13C{1H} NMR spectroscopic as well the thermal characterization of the new palladium(II) pyrazolyl complexes [PdCl2(HmPz)2] 1, [PdBr2(HmPz)2] 2, [PdI2(HmPz)2] 3, [Pd(SCN)2(HmPz)2] 4 {HmPz = 4-methylpyrazole}. The residues of the thermal decomposition were identified as Pd0 by X-ray powder diffraction. From the initial decomposition temperatures, the thermal stability of the complexes can be ordered in the sequence: 1 > 2 > 4 ≈ 3. The cytotoxic activities of the complexes and the ligand were investigated against two murine cancer cell lines: mammary adenocarcinoma (LM3) and lung adenocarcinoma (LP07) and compared to cisplatin under the same experimental conditions.
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10. Fernandes, RL, Takahashi, PM, Frem, RCG, Netto, AVG, Mauro, AE, Matos, JR. 2009 Synthesis, spectral, and thermal studies on dicarboxylate-bridged palladium(II) coordination polymers. Part I. J Therm Anal Calorim. 97:123–126. .
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13. de Almeida, ET, Santana, AM, Netto, AVG, Torres, C, Mauro, AE. 2005 Thermal study of cyclopalladated complexes of the type [Pd2(dmba)2X2(bpe)] (X=NO3 −, Cl−, N3 −, NCO−, NCS−; bpe=trans-1,2-bis(4-pyridyl)ethylene). J Therm Anal Calorim. 82:361–364. .
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14. Moro, AC, Mauro, AE, Netto, AVG, Ananias, SR, Quilles, MB, Carlos, IZ, Pavan, FR, Leite, CQF, Hörner, M. 2009 Antitumor and antimycobacterial activities of cyclopalladated complexes: X-ray structure of [Pd(C2, N-dmba)(Br)(tu)] (dmba=N,N-dimethylbenzylamine, tu=thiourea). Eur J Med Chem. 44:4611–4615. .
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| Journal of Thermal Analysis and Calorimetry | |
|---|---|
| Language | English |
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