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  • 1 Departamento de Química Geral e Inorgânica, Instituto de Química de Araraquara, UNESP-Univ Estadual Paulista, 355, Araraquara, SP, 14801-970, Brazil
  • | 2 Departamento de Análises Clínicas, Faculdade de Ciências Farmacêuticas de Araraquara, UNESP-Univ Estadual Paulista, 502, Araraquara, SP, 14801-902, Brazil
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Abstract

This study describes the synthesis, IR, 1H, and 13C{1H} NMR spectroscopic as well the thermal characterization of the new palladium(II) pyrazolyl complexes [PdCl2(HmPz)2] 1, [PdBr2(HmPz)2] 2, [PdI2(HmPz)2] 3, [Pd(SCN)2(HmPz)2] 4 {HmPz = 4-methylpyrazole}. The residues of the thermal decomposition were identified as Pd0 by X-ray powder diffraction. From the initial decomposition temperatures, the thermal stability of the complexes can be ordered in the sequence: 1 > 2 > 43. The cytotoxic activities of the complexes and the ligand were investigated against two murine cancer cell lines: mammary adenocarcinoma (LM3) and lung adenocarcinoma (LP07) and compared to cisplatin under the same experimental conditions.

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