Journal of Thermal Analysis and Calorimetry
Volume/Issue:
Volume 106: Issue 3
Application of thermal analysis and pyrolysis coupled to GC/MS in the qualification of simvastatin pharmaceutical raw material
Authors:
José Valdilânio Virgulino Procópio Department of Pharmaceutical Sciences, Unified Laboratories of Pharmaceutical Development and Assays, Federal University of Paraíba, Campus I, University City, João Pessoa, PB, 58059-970, Brazil
Department of Pharmaceutical Sciences, Postgraduate Program in Pharmaceutical Sciences, Federal University of Pernambuco, University City, Artur de Sá Avenue, Recife, PE, 50740-521, Brazil

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Valmir Gomes de Souza Department of Pharmaceutical Sciences, Unified Laboratories of Pharmaceutical Development and Assays, Federal University of Paraíba, Campus I, University City, João Pessoa, PB, 58059-970, Brazil

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Rodrigo Albuquerque da Costa Department of Pharmaceutical Sciences, Postgraduate Program in Pharmaceutical Sciences, Federal University of Pernambuco, University City, Artur de Sá Avenue, Recife, PE, 50740-521, Brazil

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Lidiane Pinto Correia Department of Pharmaceutical Sciences, Postgraduate Program in Pharmaceutical Sciences, Federal University of Pernambuco, University City, Artur de Sá Avenue, Recife, PE, 50740-521, Brazil

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Fábio Santos de Souza Department of Pharmaceutical Sciences, Unified Laboratories of Pharmaceutical Development and Assays, Federal University of Paraíba, Campus I, University City, João Pessoa, PB, 58059-970, Brazil
Department of Pharmaceutical Sciences, Postgraduate Program in Pharmaceutical Sciences, Federal University of Pernambuco, University City, Artur de Sá Avenue, Recife, PE, 50740-521, Brazil

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Rui Oliveira Macêdo Department of Pharmaceutical Sciences, Unified Laboratories of Pharmaceutical Development and Assays, Federal University of Paraíba, Campus I, University City, João Pessoa, PB, 58059-970, Brazil
Department of Pharmaceutical Sciences, Postgraduate Program in Pharmaceutical Sciences, Federal University of Pernambuco, University City, Artur de Sá Avenue, Recife, PE, 50740-521, Brazil

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Pages:
665–670
Online Publication Date:
08 Jan 2011
Publication Date:
01 Dec 2011
Article Category:
Research Article
DOI:
https://doi.org/10.1007/s10973-010-1274-y
Keywords:
Simvastatin; Thermal analysis; Pyrolysis; Thermal kinetics
Restricted access

Abstract

The simvastatin (SV) is nowadays produced semi-synthetically from lovastatin. It’s one of the statins most commonly used to treat several forms of hypercholesterolemia. This study aimed to apply the thermal characterization of the SV raw material using thermoanalytical techniques and its degradation products by Pyrolysis coupled to Gas chromatography/Mass spectrometry (Pyr-GC/MS). It was studied three samples of SV (SVA, SVB, and SVC). The results showed thermal behavior differences of the samples during the melting process transition and the activation energies (Ea) of the thermal decomposition, which were correlated to the thermal stability of them. The first decomposition step of Pyr-GC/MS showed two new compounds of m/z 284 and 207, in proportions dependents according to the pyrolysis temperature.

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  • 8. Medeiros, AFD, Santos, AFO FS de Souza Júnior, IDB, Valdilanio, J, Procópio, JVV DP de Santana Macêdo, RO 2007 Thermal studies of pre-formulates of metronidazole obtained by spray drying technique. J Therm Anal Calorim 89 3 775–781 .

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  • 11. Gomes, APB, Correia, LP, Simoes, MOS, Macêdo, RO 2007 Development of thermogravimetric method to quantitative determination of mebendazole. J Therm Anal Calorim 87 3 919–925 .

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Cover Journal of Thermal Analysis and Calorimetry
Journal of Thermal Analysis and Calorimetry
Print ISSN:
1388-6150
Online ISSN:
1572-8943

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Journal of Thermal Analysis and Calorimetry
Language English
Size A4
Year of
Foundation		 1969
Volumes
per Year		 1
Issues
per Year		 24
Founder Akadémiai Kiadó
Founder's
Address		 H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher Akadémiai Kiadó
Springer Nature Switzerland AG
Publisher's
Address		 H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible
Publisher		 Chief Executive Officer, Akadémiai Kiadó
ISSN 1388-6150 (Print)
ISSN 1588-2926 (Online)

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