View More View Less
  • 1 Department of Pharmaceutical Sciences, Postgraduate Program in Pharmaceutical Sciences, Federal University of Pernambuco, University City, Artur de Sá Avenue, Recife 50740-521, Brazil
  • | 2 Department of Pharmaceutical Sciences, Unified Laboratories of Pharmaceutical Development and Assays, Federal University of Paraíba, Campus I, University City, João Pessoa 58059-970, Brazil
Restricted access

Abstract

This work studied the thermal characterization of the pentoxifylline raw material through thermoanalytical techniques (TG, DSC, DSC-photovisual) and analysis of degradation products by Pyr-GC/MS. The picture obtained with DSC-photovisual showed the total vaporization of pentoxifylline at 230.0 °C. The TG dynamical curve presented only one step for the loss of mass evidencing to be a kinetic process of zero order reaction. The pyrograms obtained for pentoxifylline sample in the solid state and solution in the temperatures of 250.0, 300.0, and 400.0 °C, showed only one peak identifying the pentoxifylline.

  • 1. British Pharmacopoeia. London, 2009. pp. 4597602.

  • 2. Weithmann, KV. 1980 Pentoxifylline, its influence on interaction between blood vessel wall and platelets. IRCS Med Sci. 8:293.

  • 3. Oliveira, PR, Bernardi, LS, Murakami, FS, Mendes, C, Silva, MAS. Thermal characterization and compatibility studies of norfloxacin for development of extended release tablets. J Therm Anal Calorim. 2009;97:741745. .

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 4. Gombás, A, Szabó-Révész, P, Kata, M, Regdon, G, Erõs, I. Quantitative determination of crystallinity of a-lactose monohydrate by DSC. J Therm Anal Calorim. 2002;68:503510. .

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 5. Medeiros, ACD, Correia, LP, Simões, MOS, Macêdo, RO. Technological quality determination of pharmaceutical disintegrant by DSC cooling and DSC photovisual. J Therm Anal Calorim. 2007;88:311315. .

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 6. Gandhi, R, Pillai, O, Thilagavathi, R, Gopalakrishnan, B, Kaul, CL, Panchagnula, R. 2002 Characterization of azithromycin hydrates. Eur J Pharm Sci. 16:175184. .

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 7. Abbas, D, Kaloustian, J, Orneto, C, Piccerelle, P, Portugal, H, Nicolay, A. DSC and physico-chemical properties of a substituted pyridoquinoline and its interaction study with excipients. J Therm Anal Calorim. 2008;93:353360. .

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 8. Ramos, LA, Cavalheiro, ÉTG. Thermal behavior of loratadine. J Therm Anal Calorim. 2007;87:831834. .

  • 9. Giron, D. Applications of thermal analysis and coupled techniques in pharmaceutical industry. J Therm Anal Calorim. 2002;68:335357. .

  • 10. Cides, LCS, Araújo, AAS, Santos-Filho, M, Matos, JR. Thermal behaviour, compatibility study and decomposition kinetics of glimepiride under isothermal and non-isothermal conditions. J Therm Anal Calorim. 2006;84:441445. .

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 11. Tita, B, Marian, E, Tita, D, Vlase, G, Doca, N, Vlase, T. Comparative kinetic study of decomposition of some diazepine derivatives under isothermal and non-isothermal conditions. J Therm Anal Calorim. 2008;94:447452. .

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 12. Felix, FS, Cides da Silva, LC, Angnes, L, Matos, JR. Thermal behavior study and decomposition kinetics of salbutamol under isothermal and non-isothermal conditions. J Therm Anal Calorim. 2009;95:877880. .

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 13. United States Pharmacopoeia. Maryland: The United States of America. 2011. p. 3252.

  • 14. Farmacopeia Portuguesa VIII. Lisboa: Portugal. 2007. p. 2706.

  • 15. Moura, EA, Correia, LP, Pinto, MF, Procópio, JVV, de Souza, FS, Macêdo, RO. Thermal characterization of the solid state and raw material fluconazole by thermal analysis and pyrolysis coupled to GC/MS. J Therm Anal Calorim. 2010;100:289293. .

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 16. da Silva, RMF, de Medeiros, FPM, Nascimento, TG, Macêdo, RO, Neto, PJR. Thermal characterization of indinavir sulfate using TG, DSC and DSC-photovisual. J Therm Anal Calorim. 2009;95:14.

    • Search Google Scholar
    • Export Citation
  • 17. Medeiros, AFD, Santos, AFO, de Souza, FS, Basílio Júniro, ID, Procópio, JVV, de Santana, DP, Macêdo, RO. Thermal studies of pre-formulates of metronidazole obtained by spray drying technique. J Therm Anal Calorim. 2007;89:775781. .

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 18. Medeiros, AFD, Santos, AFO, de Souza, FS, Procópio, JVV, Pinto, MF, Macêdo, RO. Thermal stability of paracetamol and its pre-formulates obtained by spray drying. J Therm Anal Calorim. 2007;88:377382. .

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 19. Macêdo, RO, Nascimento, TG. 2002 Quality control of thiabendazole pre-formulation and tablets by TG and DSC coupled to the photovisual system. Thermochim Acta. 392–393:8592. .

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 20. Gomes, APB, Correia, LP, Simões, MOS, Macêdo, RO. Development of thermogravimetric method to quantitative determination of mebendazole. J Therm Anal Calorim. 2007;87:919925. .

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 21. Ikonomon, MG, Blades, AD, Kebarle, B. 1991 Electrospray mass spectrometry of methanol and water solutions suppression of electric discharge with SF6 gas. J Am Soc Mass Spectr. 2:497550. .

    • Crossref
    • Search Google Scholar
    • Export Citation

Manuscript Submission: HERE

  • Impact Factor (2019): 2.731
  • Scimago Journal Rank (2019): 0.415
  • SJR Hirsch-Index (2019): 87
  • SJR Quartile Score (2019): Q3 Condensed Matter Physics
  • SJR Quartile Score (2019): Q3 Physical and Theoretical Chemistry
  • Impact Factor (2018): 2.471
  • Scimago Journal Rank (2018): 0.634
  • SJR Hirsch-Index (2018): 78
  • SJR Quartile Score (2018): Q2 Condensed Matter Physics
  • SJR Quartile Score (2018): Q2 Physical and Theoretical Chemistry

For subscription options, please visit the website of Springer.

Journal of Thermal Analysis and Calorimetry
Language English
Size A4
Year of
Foundation
1969
Volumes
per Year
4
Issues
per Year
24
Founder Akadémiai Kiadó
Founder's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher Akadémiai Kiadó
Springer Nature Switzerland AG
Publisher's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible
Publisher
Chief Executive Officer, Akadémiai Kiadó
ISSN 1388-6150 (Print)
ISSN 1588-2926 (Online)

Monthly Content Usage

Abstract Views Full Text Views PDF Downloads
Apr 2021 5 1 1
May 2021 0 0 0
Jun 2021 1 0 0
Jul 2021 0 0 0
Aug 2021 1 0 0
Sep 2021 2 0 0
Oct 2021 0 0 0