Journal of Thermal Analysis and Calorimetry
Volume/Issue:
Volume 106: Issue 3
Polymorphic screen and drug–excipient compatibility studies of the antichagasic benznidazole
Authors:
Flávia Pires Maximiano Escola de Farmácia, Universidade Federal de Ouro Preto (UFOP), Rua Costa Sena, No 171, Centro, Ouro Preto, MG, 35400-000, Brazil

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Kátia Monteiro Novack Departamento de Química, Instituto de Ciências Exatas e Biológicas, Universidade Federal de Ouro Preto (UFOP), Campus Morro do Cruzeiro, ICEB II, sala 63, Bauxita, 35400-000, Ouro Preto, MG, Brazil

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Maria Terezinha Bahia Instituto de Ciências Exatas e Biológicas, Universidade Federal de Ouro Preto (UFOP), Campus Morro do Cruzeiro, ICEB, Bauxita, 35400-000, Ouro Preto, MG, Brazil

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Lívia Lira de Sá-Barreto Instituto de Ciências da Saúde, Campus Universitário de Sinop, Universidade Federal do Mato Grosso (UFMT), Avenida Alexandre Ferronato,1200, Reserva 35, Setor Industrial, 78557-267, Sinop, MT, Brazil

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Marcílio Sérgio Soares da Cunha-Filho Instituto de Ciências da Saúde, Campus Universitário de Sinop, Universidade Federal do Mato Grosso (UFMT), Avenida Alexandre Ferronato,1200, Reserva 35, Setor Industrial, 78557-267, Sinop, MT, Brazil

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Pages:
819–824
Online Publication Date:
15 Feb 2011
Publication Date:
01 Dec 2011
Article Category:
Research Article
DOI:
https://doi.org/10.1007/s10973-011-1371-6
Keywords:
Benznidazole; Compatibility; Differential scanning calorimetry; Fourier transform infrared spectroscopy; Polymorphism; X-ray powder diffractometry
Restricted access

Abstract

The purpose of this study was to investigate the polymorphism and compatibility of benznidazole (BNZ), a drug used in the treatment of Chagas disease. This drug was subjected to a polymorphic screen using a number of solvents and precipitation procedures to explore the possible existence of different crystal structures of BNZ. The compatibility of BNZ with selected pharmaceutical excipients was evaluated in binary mixtures, in a ratio of 1:1 (w/w). These results were then analyzed with a variety of techniques, including differential scanning calorimetry, Fourier transform infrared spectroscopy, and X-ray powder diffractometry. No polymorphic forms of BNZ were detected despite some observed changes in the DSC profile. The thermal data indicate interaction of the drug with excipients hydroxyethylcellulose, polyethylene glycol, and hydroxypropyl-β-cyclodextrin. Additional studies using infrared spectroscopy confirm the incompatibility of BNZ with only the polyethylene glycol. This excipient should not be used in the development of solid dosage forms containing BNZ.

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Cover Journal of Thermal Analysis and Calorimetry
Journal of Thermal Analysis and Calorimetry
Print ISSN:
1388-6150
Online ISSN:
1572-8943

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Journal of Thermal Analysis and Calorimetry
Language English
Size A4
Year of
Foundation		 1969
Volumes
per Year		 1
Issues
per Year		 24
Founder Akadémiai Kiadó
Founder's
Address		 H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher Akadémiai Kiadó
Springer Nature Switzerland AG
Publisher's
Address		 H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible
Publisher		 Chief Executive Officer, Akadémiai Kiadó
ISSN 1388-6150 (Print)
ISSN 1588-2926 (Online)

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