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  • 1 Department of Dermatology, Venereology and Oncodermatology, Medical School, University of Pécs, Kodály Z. str. 20, Pecs 7624, Hungary
  • 2 Surgery Clinic, Medical School, University of Pécs, Ifjúság str. 13, Pecs 7624, Hungary
  • 3 Department of Surgical Research and Techniques, Medical School, University of Pécs, Kodály Z str. 20, Pecs 7624, Hungary
  • 4 Institute of Biophysics, Faculty of Medicine, Medical School, University of Pécs, Szigeti str. 12, Pecs 7624, Hungary
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Abstract

Melanoma malignum (MM) is a common type of skin cancer, and its incidence is increasing in the general population. We aimed to detect blood plasma components with differential scanning calorimetry (DSC) in 15 white adult MM patients, who had histopathologically diagnosed, operable cutaneous MM without any distant metastases. We observed that thermal changes (second Tm, calorimetric enthalpy) in blood plasma showed correlation with tumor thickness and the extent of regional invasion. Further studies are needed to elucidate these relationships, but our preliminary work has provided DSC should be a new tool for the early diagnosis and monitoring of MM patients.

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