Journal of Thermal Analysis and Calorimetry
Volume/Issue:
Volume 108: Issue 1
Solid state studies of drugs and chemicals by dielectric and calorimetric analysis
Authors:
Dhruthiman R. Mantheni Department of Chemistry, Cleveland State University, Cleveland, OH, 44115, USA

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M. P. K. Maheswaram Department of Chemistry, Cleveland State University, Cleveland, OH, 44115, USA

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Hany F. Sobhi Department of Chemistry, Cleveland State University, Cleveland, OH, 44115, USA
Department of Natural Science, Coppin State University, Baltimore, MD, 21216, USA

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Naullage Indika Perera Department of Chemistry, Cleveland State University, Cleveland, OH, 44115, USA

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Alan T. Riga Department of Chemistry, Cleveland State University, Cleveland, OH, 44115, USA
Buckeye Diagnostics, Beachwood, OH, 44122, USA
College of Pharmacy, University of Toledo, Toledo, OH, 43606, USA

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M. Ellen Matthews Buckeye Diagnostics, Beachwood, OH, 44122, USA

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K. Alexander College of Pharmacy, University of Toledo, Toledo, OH, 43606, USA

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Pages:
227–233
Online Publication Date:
11 Apr 2011
Publication Date:
01 Apr 2012
Article Category:
Research Article
DOI:
https://doi.org/10.1007/s10973-011-1423-y
Keywords:
Dielectric thermal analysis; Differential scanning calorimetry; Premelt; Activation energy; Active pharmacy ingredients; Amino acids; Carbohydrates; Polymers; Organic compounds
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Abstract

Novel dielectric behavior of a linear increase in ionic conductivity prior to melt temperature was observed for active pharmaceutical ingredients (APIs), organic chemicals, amino acids, and carbohydrates. Though, there are solids like polyolefins and long chain organic compounds (tetracosane, pentacosane) which do not exhibit this premelt behavior (i.e., the temperature where the onset of increase in ionic conductivity to melt temperature). We have discovered novel electrical conductivity properties and other physical analytical variations which can lead to unique synthetic routes of certain chemical entities. The above-mentioned unique variations are not related to solid–solid transitions which are quite often observed in pharmaceutical crystalline solids. These new properties are related to amorphous crystalline behavior of a solid. We have also studied the effect of various experimental variables: such as amount of mass tested, applied frequency at a given electric field and heating rate, which results in varying the onset temperature of the increase in ionic conductivity. Melting of the solids was correlated using differential scanning calorimetry (DSC). Activation energies for all the solids were measured in the premelt region using an Arrhenius plot at a specific frequency since we observed changes in the conductivity with frequency. This study focused on frequencies 0.1 to 10 Hz, since the conductivity at these frequencies related to surface analysis. This new physical properties are leading to new electro synthetic procedures to modify or prepare chemicals.

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Cover Journal of Thermal Analysis and Calorimetry
Journal of Thermal Analysis and Calorimetry
Print ISSN:
1388-6150
Online ISSN:
1572-8943

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Journal of Thermal Analysis and Calorimetry
Language English
Size A4
Year of
Foundation		 1969
Volumes
per Year		 1
Issues
per Year		 24
Founder Akadémiai Kiadó
Founder's
Address		 H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher Akadémiai Kiadó
Springer Nature Switzerland AG
Publisher's
Address		 H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible
Publisher		 Chief Executive Officer, Akadémiai Kiadó
ISSN 1388-6150 (Print)
ISSN 1588-2926 (Online)

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