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  • 1 Universidade Federal do Rio Grande do Norte, Natal, Brazil
  • | 2 Programa de Pós-Graduação Desenvolvimento e Inovação Tecnológica de Medicamentos, UFRN, Natal, Brazil
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Abstract

Warifteine and methylwarifteine are bisbenzylisoquinoline alkaloids from Cissampelos sympodialis Eichl., produces a reversible, nonspecific, and noncompetitive antagonism of histamine, anti-allergic therapy, and used in the folk medicine for the treatment of airway respiratory diseases. Thermal techniques are used for several purposes, e.g., for thermal characterization, and measurement of the vapor pressure with objective of the quantitative determination. The objective of this study was to evaluate of the vapor pressure of the curves of warifteine and methylwarifteine by thermogravimetry analysis, how a fast and sensible method for quantitative determination. This method is based on the ratio of the Arrhenius, Langmuir, and Antoine equations for a reference material and the sample under investigation. The results showed these alkaloids follow zero-order kinetics with respect to volatilization. The vapor pressure curves of warifteine and methylwarifteine were plotted for the rates of 10, 15, and 20 °C min−1. The proposed method also possesses the potential.

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