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  • 1 China Military Institute of Chinese Materia Medica, 302 Military Hospital of China, Beijing 100039, People’s Republic of China
  • | 2 Pharmacy College, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, People’s Republic of China
  • | 3 College of Chemistry and Biotechnology, Chongqing University of Technology, Chongqing 400050, People’s Republic of China
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Abstract

Rhizoma Coptidis consists mainly of protoberberine alkaloids (PAs), and has been used for many years as a traditional medicine. Recent research revealed the toxicity of Rhizoma Coptidis, but studies focusing on the relationships between the structures of PAs and their toxicities are lacking. The toxic effects of four PAs from Rhizoma Coptidis on the growth of Tetrahymena thermophila BF5 were investigated by microcalorimetry. The power-time curves of T. thermophila BF5 with and without PAs were obtained; the extent and duration of toxic effects on the metabolism of this organism were evaluated by studying thermokinetic parameters and the half-inhibitory ratio (IC50). All the thermokinetic parameters showed regular variations with alteration of PA concentrations. The magnitude of the toxic effects of PAs was ascertained from IC50 values: palmatine > jateorhizine > berberine ≈ coptisine. The structure–function relationship of PAs indicated that the C2 and C3 positions contributed more to the toxic effect of PAs. That is, when substituted with methoxyl groups, the toxic effect would be increased.

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  • Impact Factor (2019): 2.731
  • Scimago Journal Rank (2019): 0.415
  • SJR Hirsch-Index (2019): 87
  • SJR Quartile Score (2019): Q3 Condensed Matter Physics
  • SJR Quartile Score (2019): Q3 Physical and Theoretical Chemistry
  • Impact Factor (2018): 2.471
  • Scimago Journal Rank (2018): 0.634
  • SJR Hirsch-Index (2018): 78
  • SJR Quartile Score (2018): Q2 Condensed Matter Physics
  • SJR Quartile Score (2018): Q2 Physical and Theoretical Chemistry

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Journal of Thermal Analysis and Calorimetry
Language English
Size A4
Year of
Foundation
1969
Volumes
per Year
4
Issues
per Year
24
Founder Akadémiai Kiadó
Founder's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher Akadémiai Kiadó
Springer Nature Switzerland AG
Publisher's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible
Publisher
Chief Executive Officer, Akadémiai Kiadó
ISSN 1388-6150 (Print)
ISSN 1588-2926 (Online)

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