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  • 1 C.S.G.I., Department of Chemistry, Section of Physical Chemistry, University of Pavia, Viale Taramelli 16, 27100, Pavia, Italy
  • | 2 Aptuit Srl, Via Fleming 4, 37135, Verona, Italy
  • | 3 GlaxoSmithKline SpA, Via Fleming 2, 37135, Verona, Italy
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Abstract

In this study, we present a full thermal characterization of antidepressant paroxetine and summarize the results for another drug which treats depression: GW597599B. The main aim is to analyze how the thermodynamic and structural properties of these compounds are modified when the two drugs are mixed in the solid state. We begin by putting into evidence how dehydration and melting concur in shaping the calorimetric curves of paroxetine under different experimental conditions. Equipped with this knowledge, we are able to interpret the thermal response of the physical mixtures paroxetine:GW597599B, in terms of partial eutectic formation and simple superposition of contribution from the two compounds.

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Manuscript Submission: HERE

  • Impact Factor (2019): 2.731
  • Scimago Journal Rank (2019): 0.415
  • SJR Hirsch-Index (2019): 87
  • SJR Quartile Score (2019): Q3 Condensed Matter Physics
  • SJR Quartile Score (2019): Q3 Physical and Theoretical Chemistry
  • Impact Factor (2018): 2.471
  • Scimago Journal Rank (2018): 0.634
  • SJR Hirsch-Index (2018): 78
  • SJR Quartile Score (2018): Q2 Condensed Matter Physics
  • SJR Quartile Score (2018): Q2 Physical and Theoretical Chemistry

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Journal of Thermal Analysis and Calorimetry
Language English
Size A4
Year of
Foundation
1969
Volumes
per Year
4
Issues
per Year
24
Founder Akadémiai Kiadó
Founder's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher Akadémiai Kiadó
Springer Nature Switzerland AG
Publisher's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible
Publisher
Chief Executive Officer, Akadémiai Kiadó
ISSN 1388-6150 (Print)
ISSN 1588-2926 (Online)

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